
Linearquadratic
dose response 
A linearquadratic dose
response is a relationship between dose
and biological response that is curved. This implies
that the rate of change in response is different at different
doses. The response may change slowly at low doses, for
example, but rapidly at high doses. A linearquadratic
dose response is written mathematically as follows: if Y represents
the expected, or average response and D represents
dose, then
Y = aD + bD^{2}
where a is the linear coefficient (or slope) and b is
the quadratic coefficient (or curvature).
See also Dose
response, Threshold
dose, and Linear
dose response. 

