Tatsuaki Tsuruyama

Affiliation

Department of Molecular Biosciences
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About

Dr. Tsuruyama started pathology research at Kyoto University. He has been developing biophysical image analysis technology using pathological methods, omics analysis based on the physical characteristics of pathological samples, and cell biology research focusing on malignant lymphoma and other cancers.

1. Proteomics (Mass spectrometry imaging)
2. Biophysics (Signal transduction)
3. Cancer genome (Viral insertion target sequence and oncogenes responsible for malignant lymphoma)
4. Immunopathology (Mucosal immunity, surveillance, tolerance, and rejection)

Education

2002
Ph.D Pathology, Graduate School of Medicine, Kyoto University
1998
Graduate School of Medicine, Kyoto University, Course certification
1995
Graduate School of Medicine, Kyoto University Entry

Experience

2022-
Visiting Professor, Graduate School of Medicine, Department of Cell Response Pathology, Hiroshima University
2021-
Senior Scientist and Laboratory Chief, Laboratory of Molecular Pathology, Department of Molecular Biosciences, Radiation Effects Research Foundation
2021-
Visiting Professor, Graduate School of Science, Department of Physics, Tohoku University
2016-
Visiting Professor of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University
2020-2021
Research fellow, TazukeKofukai Medical Institute Kitano Hospital, Visiting Researcher, Graduate School of Medicine, Kyoto University
2012-2016
Associate Professor, Anatomic Research Center, Graduate School of Medicine, Kyoto University
2008-2012
Associate Professor, Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University
2005-2008
Lecturer, Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University
1998-2005
Assistant Professor, Graduate School of Medicine, Kyoto University

Selected publications

Tsuruyama T. Nonlinear Thermodynamics of Biological Signal Transduction for Predicting Conservation of Entropy Production Rate. Journal of Theoretical Biology. 2021; 523:110716.
Tsuruyama T. Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate. Journal of Theoretical Biology. 2019; 472, 84-87.
Yajima Y., Hiratsuka T., Kakimoto Y., Ogawa S., Shima K., Yamazaki Y., Yoshikawa K., Tamaki K. & Tsuruyama T. Mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue. Scientific Reports. 2018; 8, 7493.
Tsuruyama T. Information Thermodynamics Derives the Entropy Current of Cell Signal Transduction as a Model of a Binary Coding System. Entropy. 2018; 20, 145.
Hiratsuka T., Takei Y., Ohmori R., Imai Y., Ozeki M., Tamaki K., Haga H., Nakamura T., Tsuruyama T. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene. 2016; 35, 3227-38.
Ma X., Aoki T., Tsuruyama T., Narumiya S. Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment which amplify inflammation and tumor growth. Cancer Research. 2015; 75, 2822-2832.
Kakimoto Y., Ito S., Abiru H., Kotani H., Ozeki M., Tamaki K., Tsuruyama T. Sorbin and SH3 domain-containing protein 2 is released from infarcted heart in the very early phase: proteomic analysis of cardiac tissues from patients. Journal of American Heart Association. 2013; 2, e000565.
Kotani A., Kakazu N., Tsuruyama T., Okazaki IM., Muramatsu M., Kinoshita K., Nagaoka H., Yabe D. & Honjo T. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104, 1616-1620.
Tachibana T., Onodera H., Tsuruyama T., Mori A., Nagayama S., Hiai H. & Imamura M. Increased intratumor Valpha24-positive natural killer T cells: a prognostic factor for primary colorectal carcinomas. Clinical Cancer Research. 2005; 11, 7322-7327.
Tsuruyama T., Nakamura T., Jin G., Ozeki M., Yamada Y. & Hiai H. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99, 8253-8258.

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