Tatsuaki Tsuruyama
Affiliation
Department of Molecular Biosciences
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About
Dr. Tsuruyama started pathology research at Kyoto University. He has been developing biophysical image analysis technology using pathological methods, omics analysis based on the physical characteristics of pathological samples, and cell biology research focusing on malignant lymphoma and other cancers.
1. Proteomics (Mass spectrometry imaging)
2. Biophysics (Signal transduction)
3. Cancer genome (Viral insertion target sequence and oncogenes responsible for malignant lymphoma)
4. Immunopathology (Mucosal immunity, surveillance, tolerance, and rejection)
1. Proteomics (Mass spectrometry imaging)
2. Biophysics (Signal transduction)
3. Cancer genome (Viral insertion target sequence and oncogenes responsible for malignant lymphoma)
4. Immunopathology (Mucosal immunity, surveillance, tolerance, and rejection)
Education
- 2002
- Ph.D Pathology, Graduate School of Medicine, Kyoto University
- 1998
- Graduate School of Medicine, Kyoto University, Course certification
- 1995
- Graduate School of Medicine, Kyoto University Entry
Experience
- 2022-
- Senior Scientist, Assistant Department Chief, Department of Molecular Biosciences, Radiation Effects Research Foundation
- 2022-
- Visiting Professor, Graduate School of Medicine, Department of Cell Response Pathology, Hiroshima University
- 2021-
- Senior Scientist and Laboratory Chief, Laboratory of Molecular Pathology, Department of Molecular Biosciences, Radiation Effects Research Foundation
- 2021-
- Visiting Professor, Graduate School of Science, Department of Physics, Tohoku University
- 2016-
- Visiting Professor of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University
- 2020-2021
- Research fellow, TazukeKofukai Medical Institute Kitano Hospital, Visiting Researcher, Graduate School of Medicine, Kyoto University
- 2012-2016
- Associate Professor, Anatomic Research Center, Graduate School of Medicine, Kyoto University
- 2008-2012
- Associate Professor, Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University
- 2005-2008
- Lecturer, Forensic Medicine and Molecular Pathology, Graduate School of Medicine, Kyoto University
- 1998-2005
- Assistant Professor, Graduate School of Medicine, Kyoto University
Selected publications
- Tsuruyama T. Nonlinear Thermodynamics of Biological Signal Transduction for Predicting Conservation of Entropy Production Rate. Journal of Theoretical Biology. 2021; 523:110716.
- Tsuruyama T. Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate. Journal of Theoretical Biology. 2019; 472, 84-87.
- Yajima Y., Hiratsuka T., Kakimoto Y., Ogawa S., Shima K., Yamazaki Y., Yoshikawa K., Tamaki K. & Tsuruyama T. Mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue. Scientific Reports. 2018; 8, 7493.
- Tsuruyama T. Information Thermodynamics Derives the Entropy Current of Cell Signal Transduction as a Model of a Binary Coding System. Entropy. 2018; 20, 145.
- Hiratsuka T., Takei Y., Ohmori R., Imai Y., Ozeki M., Tamaki K., Haga H., Nakamura T., Tsuruyama T. ZFP521 contributes to pre-B-cell lymphomagenesis through modulation of the pre-B-cell receptor signaling pathway. Oncogene. 2016; 35, 3227-38.
- Ma X., Aoki T., Tsuruyama T., Narumiya S. Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment which amplify inflammation and tumor growth. Cancer Research. 2015; 75, 2822-2832.
- Kakimoto Y., Ito S., Abiru H., Kotani H., Ozeki M., Tamaki K., Tsuruyama T. Sorbin and SH3 domain-containing protein 2 is released from infarcted heart in the very early phase: proteomic analysis of cardiac tissues from patients. Journal of American Heart Association. 2013; 2, e000565.
- Kotani A., Kakazu N., Tsuruyama T., Okazaki IM., Muramatsu M., Kinoshita K., Nagaoka H., Yabe D. & Honjo T. Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104, 1616-1620.
- Tachibana T., Onodera H., Tsuruyama T., Mori A., Nagayama S., Hiai H. & Imamura M. Increased intratumor Valpha24-positive natural killer T cells: a prognostic factor for primary colorectal carcinomas. Clinical Cancer Research. 2005; 11, 7322-7327.
- Tsuruyama T., Nakamura T., Jin G., Ozeki M., Yamada Y. & Hiai H. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99, 8253-8258.