RP 3-11

Radiation exposure in children and in utero survivors of the atomic bombing of Hiroshima and Nagasaki and late-life neurocognitive function


We will examine late-life neurocognitive function among the Adult Health Study (AHS) subjects who were exposed in utero or aged <12 years at the time of the atomic bombing of Hiroshima and Nagasaki. Objectives, are (1) to examine associations between radiation exposure and neurocognitive function as assessed by neuropsychological examination, (2) to investigate the effects of sex, age, attained education, lifestyle, and comorbidity on neurocognitive function as risk factors or modifiers of radiation effects, and (3) to collect baseline data on cognitive function for the investigation of longitudinal progression in cognitive decline with advancing age and the occurrence of dementia. The Cognitive Abilities Screening Instrument (CASI) and the Childhood Cancer Survivors Study (CCSS)-Neurocognitive Questionnaire (NCQ) will be used as instruments for neuropsychological assessment.