contents.txt 10/11/94 1 The files on these disks include detailed tabulations and documentation of the data used in the analyses of LSS cancer incidence for the period from 1958-1987 for solid cancer and 1950-1987 for leukemia, lymphoma, and myeloma. The papers by Thompson et. al. [Radiation Research Supplement, Volume 137, Number 2, 1994] and Preston et. al. [Radiation Research Supplement, Volume 137, Number 2, 1994] present the results of RERF's analyses of these data. In the analyses in Thompson et. al. [Radiation Research Supplement, Volume 137, Number 2, 1994] separate person-year tabulations were made for each organ dose. The solid cancer table included here was defined using colon dose (TR87DATA.DAT). In order to allow you to carry out analyses based on doses to the other organs, we have included a table of city and age at exposure specific organ dose adjustment factors (DS86ADJF.DAT). The leukemia, lymphoma, and myeloma cancer table included was defined using bone marrow dose (HEMA87.DAT). Disk # Data file Description 1 TR87DATA.DAT LSS solid cancer incidence file 1 DS86ADJF.DAT Organ dose adjustment factor file 2 HEMA87.DAT Leukemia incidence file Documentation 1 DOCUMENT.TXT Documentation for the above three data files 1 CONTENTS.TXT Descriptions for all of the files in the disks Sample analysis script file 1 TR87DATA.SCR Script file for reading TR87DATA.DAT 1 TR87MOD.SCR Script file to fit the basic models 1 DS86ADJF.SCR Script file for computation of other organ doses using factors from DS86ADJF.DAT 2 HEMA87.SCR Script file for reading HEMA87.DAT 2 HEMAMOD.SCR Script file to fit the basic models of leukemia, lymphoma, and myeloma Sample analysis log file 1 TR87DATA.LOG Log file of TR87DATA.SCR and TR87MOD.SCR 2 HEMA87.LOG Log file of HEMA87.SCR and HEMAMOD.SCR The solid cancer and leukemia data sets are detailed tabulations of person years, case counts, and summary data constructed from data on individual survivors. The population for the solid tumor data set includes data on 80,206 survivors while the leukemia data set includes information on 86,594 survivors. These totals include survivors with DS86 shielded kerma estimates greater than 4 Gy. The data sets are structured to make it easy to exclude survivors with total shielded kerma estimates above 4 Gy as was done in the published reports. The solid tumor data set is based on data obtained from the Hiroshima and Nagasaki tumor registries together with LSS mortality follow-up data. Since the tumor registries did not start operation until 1958, follow-up is limited to the period from 1958 to 1987. The ABCC/RERF leukemia registry was the primary source of data on the incidence of leukemia, lymphoma, and myeloma incidence however, data were also obtained from the Hiroshima and Nagasaki tumor registries Because of the availability of the Leukemia Registry data follow-up for the leukemia data set begins on October 1, 1950. The difference in the number of survivors on the two data sets is a consequence of the different starting dates for the follow-up periods. As in the principal analyses of the papers noted above, case counts are limited to first primary cancers diagnosed in the registry catchment area. Data on individual survivors were stratified on city, sex, age at exposure (five year intervals), calendar time, and dose to produce these data sets. Dose categories in the leukemia data set are defined in terms of total bone marrow dose while dose categories in the solid cancer table are defined using total dose to the colon. The leukemia data set is identical to that used in the analyses of Preston et al. The solid cancer data set is identical to that used in the pooled analysis of all solid tumors and in the analyses of colon cancer risks. However, other site-specific analyses in Thompson et al were based on data sets of the same basic form in which the data were grouped by the appropriate organ dose. It is impractical to distribute all of these data sets. However, as noted above, the disks contain city and age at exposure specific conversion factors that can be used to compute estimates of doses to other organs along with a command script that provides an explicit illustration of how one can use these factors compute doses for other organs. Each record in the main data files includes indicators of sex, city, organ dose category, age-at-exposure category, calendar time period, and other factors. The basic data for each record in these tables include: person years, migration adjusted person years, the number of people entering the study, mean values of attained age, age at exposure, time since exposure, and year. Doses are summarized by the mean values of the gamma and neutron organ doses and the mean RBE 10 weighted total organ dose (i.e. gamma dose plus ten times the neutron dose). The solid tumor table includes case counts for all solid tumors as a group and for 31 specific tumor types. The leukemia table includes counts for all lymphomas, non-Hodgkin's lymphomas, multiple myeloma, all leukemias, acute myelogenous leukemia, chronic myelogenous leukemia, acute lymphocytic leukemia, and adult T-cell leukemia. The solid tumor data set has 3249 records while the leukemia data set has 4894 records. The files are ASCII text files in which the records have a fixed format and fields are separated by blanks so that they can easily be read into spreadsheets or other data analysis programs. In addition to detailed documentation of the content of each of the data files, EPICURE command script and log files for fitting some of the models that were used in the analyses for the published cancer incidence reports are also included on the disk. The models that can be fit using these scripts include: those used for the standard excess relative risk estimates for solid cancers and excess absolute risk models for all leukemias, non-Hodgkin's lymphoma, and multiple myeloma. These scripts also illustrate how the data can be read and how to convert colon dose estimates to approximate values for other organs. If these data are used as the basis for analyses in any publication including working papers or technical reports, a statement of acknowledgment must be included in the manuscript. This statement should read: This report makes use of data obtained from the Radiation Effects Research Foundation (RERF) in Hiroshima, Japan. RERF is a private foundation funded equally by the Japanese Ministry of Health and Welfare and the U.S. Department of Energy through the U.S. National Academy of Sciences. The conclusions in this report are those of the authors and do not necessarily reflect the scientific judgment of RERF or its funding agencies. Please send a copy of any reprints which make use of these data to: Administration and Support Section Publication and Documentation Center Radiation Effects Research Foundation 5-2 Hijiyama Koen Minami-ku Hiroshima Shi 732 JAPAN Persons interested in obtaining a copy of these data should contact the RERF Publication and Documentation Center 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732 Japan (facsimile +81-82-263-7279). The cost per disk is US$50. All of the files are included on two single 3.5 inch 1.4 MB MS-DOS formatted floppy disk. However 5.25 inch disks can be made upon request.