Increased frequency of CD4-8- T cells bearing T-cell receptor alpha-beta chains in peripheral blood of atomic bomb survivors exposed to high doses

Kusunoki Y, Kyoizumi S, Hirai Y, Fujita S, Akiyama M
Radiat Res 139:67-72, 1994

Summary

A rare T-cell subpopulation, CD4^–8^– alpha-beta T cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4⁺ or CD8⁺ T cells. In the present study, the frequencies of CD4^–8^– T cells in peripheral-blood alpha-beta T cells in 409 atomic bomb survivors (160 estimated to have been exposed to 1.5 Gy or more and 249 controls) were determined to investigate late effects of radiation on the composition of human T-cell subpopulations. The frequency of CD4^–8^– alpha-beta T-cell decreased significantly with the subject’s age and was higher in females than males. A significant increase in the frequency was found in the survivors exposed to more than 1.5 Gy, suggesting that the previous radiation exposure altered differentiation and development of T cells.