Technical Report No. 4-85
Electrophoretic variants of blood proteins in Japanese. V. Ceruloplasmin
Fujita M, Satoh C, Asakawa J, Nagahata Y, Tanaka Y, Hazama R, Goriki KEditor’s note: A publication based on this report was published in Jpn J Hum Genet 30:43-50, 1985.
Summary
The plasma ceruloplasmin (CP) of 22,367 children of atomic bomb survivors in Hiroshima and Nagasaki was examined for variants by electrophoresis. The sample was composed of 14,964 unrelated children and 7,403 siblings of the unrelated persons. A total of seven types of electrophoretic variants were detected; four migrating anodally and three cathodally to the normal B band. We have reported two of these variants, CP ANG1 and CP CNG1, previously but the other five, CP ANG2, CP AHR1, CP AHR2, CP CHR1, and CP CHR2, are newly identified. The allelic frequency of CP*CNG1 was 0.00916, so that the variant is considered to be a polymorphic allele. Homozygosity for the CP*CNG1 allele was detected in five individuals. This is the first report of a homozygous phenotype for a CP variant in a Japanese population. Family study of the new five variants all demonstrated patterns of codominant inheritance.
The plasma ceruloplasmin (CP) of 22,367 children of atomic bomb survivors in Hiroshima and Nagasaki was examined for variants by electrophoresis. The sample was composed of 14,964 unrelated children and 7,403 siblings of the unrelated persons. A total of seven types of electrophoretic variants were detected; four migrating anodally and three cathodally to the normal B band. We have reported two of these variants, CP ANG1 and CP CNG1, previously but the other five, CP ANG2, CP AHR1, CP AHR2, CP CHR1, and CP CHR2, are newly identified. The allelic frequency of CP*CNG1 was 0.00916, so that the variant is considered to be a polymorphic allele. Homozygosity for the CP*CNG1 allele was detected in five individuals. This is the first report of a homozygous phenotype for a CP variant in a Japanese population. Family study of the new five variants all demonstrated patterns of codominant inheritance.