Technical Report No. 11-85
Diabetes, glycosuria, and proteinuria in a Japanese cohort followed for 20 years
Brodsky JB, Moore DF, Ohara JL, Kawate R, Hamilton HBSummary
An analysis of noninsulin-dependent diabetes mellitus, glycosuria, and proteinuria in a Japanese cohort, which has been followed for 20 years, is presented. For the last 14 years of follow-up in Hiroshima, the sex-specific incidence rates of diabetes were approximately constant at 1.2-1.4 cases/100 per 2-year interval for males (p > .50) and at 0.5-0.6 cases/100 per 2-year interval for females (p > .20). The diagnosis of diabetes depended on first screening for glycosuria and then administering an oral glucose tolerance test only to those with glycosuria. The relatively greater prevalence of glycosuria and diabetes among males has also been noted by others using similar methods. It has been reported elsewhere that if the glucose tolerance test were used to screen for diabetes, the sex difference may not be apparent. The prevalence of diabetes increased over the course of study (p < .001), and the increase was attributed to aging of the cohort. The size of the undiagnosed diabetic population was estimated and the observed prevalence rate was determined to be about 75% of the actual prevalence rate at the end of 8 years of follow-up and to be about 89% of the actual prevalence rate at the end of 20 years of follow-up. Proteinuria prevalence was 4.3% in nondiabetics, 23.5% in Hiroshima diabetics, and 18.7% in Nagasaki diabetics. The differences in prevalence rates between nondiabetics and diabetics were highly significant (p < .001).
An analysis of noninsulin-dependent diabetes mellitus, glycosuria, and proteinuria in a Japanese cohort, which has been followed for 20 years, is presented. For the last 14 years of follow-up in Hiroshima, the sex-specific incidence rates of diabetes were approximately constant at 1.2-1.4 cases/100 per 2-year interval for males (p > .50) and at 0.5-0.6 cases/100 per 2-year interval for females (p > .20). The diagnosis of diabetes depended on first screening for glycosuria and then administering an oral glucose tolerance test only to those with glycosuria. The relatively greater prevalence of glycosuria and diabetes among males has also been noted by others using similar methods. It has been reported elsewhere that if the glucose tolerance test were used to screen for diabetes, the sex difference may not be apparent. The prevalence of diabetes increased over the course of study (p < .001), and the increase was attributed to aging of the cohort. The size of the undiagnosed diabetic population was estimated and the observed prevalence rate was determined to be about 75% of the actual prevalence rate at the end of 8 years of follow-up and to be about 89% of the actual prevalence rate at the end of 20 years of follow-up. Proteinuria prevalence was 4.3% in nondiabetics, 23.5% in Hiroshima diabetics, and 18.7% in Nagasaki diabetics. The differences in prevalence rates between nondiabetics and diabetics were highly significant (p < .001).