Technical Report No. 4-86
Cellular immunity of patients with lung cancer and other lung diseases. 1. Analysis of peripheral blood lymphocyte subsets using monoclonal antibodies
Fujiwara S, Akiyama M, Kobuke K, Ichimaru S, Takaishi M, Inamizu T, Kohno N, Takami S, Noumi K, Kawamoto M, Yamakido MEditor’s note: A publication based on this report was published in Hiroshima J Med Sci 35:227-36, 1986.
Summary
Lymphocyte subsets and lymphocyte responsiveness to mitogens were examined for lung disease patients and healthy people. The results are as follows: 1) Lymphocyte subsets derived from healthy persons showed an age-dependent increase in percentage of Leu-7+ cells and a decrease in reactivity to phytohemagglutinin (PHA). The percentages of Leu-1+ and Leu-3a+ cells were higher in females than in males under 30 years of age, while percentage of Leu-7+ cells was higher in males at all ages, 2) Untreated lung cancer patients showed decreases in the percentage of Leu-1+ cells and reactivity to PHA and concanavalin A, and an increase in the percentage of Leu-11a+ cells, 3) When lymphocyte subsets were compared between healthy group and patients at each cancer stage, decreased percentages of Leu-1+ and Leu-3a+ in patients with stage IV cancer and Leu-2a+ in those with stage I were observed, while the percentage of Leu-11a+ cells was high in stages I and III patients, 4) No difference in lymphocyte subsets of lung cancer patients in relation to histological type was observed, and 5) Among noncancerous respiratory diseases patients, there was a reduced percentage of Leu-1+ cells in sarcoidosis and pulmonary emphysema, and reduced percentages of Leu-1+ and Leu-3a+ cells in pulmonary fibrosis and diffuse panbronchiolitis.
Lymphocyte subsets and lymphocyte responsiveness to mitogens were examined for lung disease patients and healthy people. The results are as follows: 1) Lymphocyte subsets derived from healthy persons showed an age-dependent increase in percentage of Leu-7+ cells and a decrease in reactivity to phytohemagglutinin (PHA). The percentages of Leu-1+ and Leu-3a+ cells were higher in females than in males under 30 years of age, while percentage of Leu-7+ cells was higher in males at all ages, 2) Untreated lung cancer patients showed decreases in the percentage of Leu-1+ cells and reactivity to PHA and concanavalin A, and an increase in the percentage of Leu-11a+ cells, 3) When lymphocyte subsets were compared between healthy group and patients at each cancer stage, decreased percentages of Leu-1+ and Leu-3a+ in patients with stage IV cancer and Leu-2a+ in those with stage I were observed, while the percentage of Leu-11a+ cells was high in stages I and III patients, 4) No difference in lymphocyte subsets of lung cancer patients in relation to histological type was observed, and 5) Among noncancerous respiratory diseases patients, there was a reduced percentage of Leu-1+ cells in sarcoidosis and pulmonary emphysema, and reduced percentages of Leu-1+ and Leu-3a+ cells in pulmonary fibrosis and diffuse panbronchiolitis.