Technical Report No. 13-87
An autopsy study of histopathologic changes in the urinary bladder transitional epithelium of atomic bomb survivors, 1960-83
Eto R, Ishimaru T, Tokunaga MEditor’s note: A publication based on this report was published in Hiroshima J Med Sci 37:11-15, 1988.
Summary
In the ABCC-RERF Life Span Study extended sample, 4,499 persons who were the subjects of the Pathology Study of atomic bomb survivors were autopsied in the period 1960-83. Among 370 subjects who were heavily exposed with an estimated dose (T65D) of 100 rad or more, 72 (about 20%), whose urinary bladder epithelia had been preserved satisfactorily to suit the purpose of this study, were selected as the index group. An equal number of control subjects were selected from the nonexposed group, matched with the index cases by city, sex, age at death, and year of death. However, cases with marked epithelial autolysis and those pathologically diagnosed as urinary bladder cancer were excluded from the study subjects for the index and control groups. These 72 pairs of autopsy cases were pathologically studied for the presence of epithelial lesions of the urinary bladder, namely, hyperplasia, dysplasia, and carcinoma-in-situ, and the frequencies of appearance of these lesions were compared statistically by chi2 test based on a case-control study design.
Carcinoma-in-situ and severe dysplasia were detected in neither the index nor the control cases. The risk was relatively higher in the index group than in the control group for both hyperplasia and dysplasia (mild and moderate), in particular the relative risk of papillary hyperplasia being about 4.0, but as the total number of cases was small, this was not statistically significant.
In the ABCC-RERF Life Span Study extended sample, 4,499 persons who were the subjects of the Pathology Study of atomic bomb survivors were autopsied in the period 1960-83. Among 370 subjects who were heavily exposed with an estimated dose (T65D) of 100 rad or more, 72 (about 20%), whose urinary bladder epithelia had been preserved satisfactorily to suit the purpose of this study, were selected as the index group. An equal number of control subjects were selected from the nonexposed group, matched with the index cases by city, sex, age at death, and year of death. However, cases with marked epithelial autolysis and those pathologically diagnosed as urinary bladder cancer were excluded from the study subjects for the index and control groups. These 72 pairs of autopsy cases were pathologically studied for the presence of epithelial lesions of the urinary bladder, namely, hyperplasia, dysplasia, and carcinoma-in-situ, and the frequencies of appearance of these lesions were compared statistically by chi2 test based on a case-control study design.
Carcinoma-in-situ and severe dysplasia were detected in neither the index nor the control cases. The risk was relatively higher in the index group than in the control group for both hyperplasia and dysplasia (mild and moderate), in particular the relative risk of papillary hyperplasia being about 4.0, but as the total number of cases was small, this was not statistically significant.