Technical Report No. 8-90
Hyperparathyroidism among atomic bomb survivors in Hiroshima, 1986-88
Fujiwara S, Ezaki H, Sposto R, Akiba S, Neriishi K, Kodama K, Yoshimitsu K, Hosoda Y, Shimaoka KEditor’s note: A publication based on this report was published in J Radiat Res (Tokyo) 32S:245-8, 1991.
Summary
During the two-year period from August 1986 to July 1988, the prevalence of hyperparathyroidism (HPT) was determined among A-bomb survivors and unexposed control subjects in Hiroshima. The diagnosis of HPT was determined biochemically, based upon the presence of consistent hypercalcemia and elevated serum parathyroid hormone levels. Among a population of 4,675 individuals (1,527 males, 3,148 females), primary HPT was diagnosed in 22 (3 males, 19 females). Of these, 8 underwent surgery, of whom 6 had a single parathyroid adenoma and 2 had parathyroid hyperplasia.
HPT was more prevalent among the A-bomb survivors who received higher radiation doses (p < .001 for linear trend). The prevalence rates predicted from the model were 0.204% (plus or minus 0.094%) at 0 Gy and 0.893% (plus or minus 0.237%) at 1 Gy. The background rate of HPT did not differ significantly by sex or by age at the time of the bombing, although the effect of radiation exposure was greater for individuals exposed at a younger age (p < .01).
During the two-year period from August 1986 to July 1988, the prevalence of hyperparathyroidism (HPT) was determined among A-bomb survivors and unexposed control subjects in Hiroshima. The diagnosis of HPT was determined biochemically, based upon the presence of consistent hypercalcemia and elevated serum parathyroid hormone levels. Among a population of 4,675 individuals (1,527 males, 3,148 females), primary HPT was diagnosed in 22 (3 males, 19 females). Of these, 8 underwent surgery, of whom 6 had a single parathyroid adenoma and 2 had parathyroid hyperplasia.
HPT was more prevalent among the A-bomb survivors who received higher radiation doses (p < .001 for linear trend). The prevalence rates predicted from the model were 0.204% (plus or minus 0.094%) at 0 Gy and 0.893% (plus or minus 0.237%) at 1 Gy. The background rate of HPT did not differ significantly by sex or by age at the time of the bombing, although the effect of radiation exposure was greater for individuals exposed at a younger age (p < .01).