カリフォルニア大学サンフランシスコ校　教授、科学政策・戦略担当副総長、精密医療担当部長

必須ホルモンと細胞シグナルの活動を仲介する、核内受容体による転写制御の研究を国際的に主導。具体的には純粋な分子、細胞、および全生物中に存在するこれらの問題を追及するために機序的・体系的な方法を用いる。

私の研究室では30名以上の大学院生、および60名以上の博士研究員がこれまでに学んでいる。その多くは学術研究・機関運営の道に留まり、一部は製薬・生命工学研究と運営、さらに教育、ビジネス、情報伝達、法律、および政治に関連する職業においてその科学教育を活かしている。研究室で学んだ卒業生の中にはそれぞれの分野でリーダー的立場にいる者もおり、誇りに思っている。

1.

UCSF: Biochemistry and Molecular Biology (BMB) Graduate Program. Helped to develop curriculum; conceived and helped teach core graduate foundation Biological Regulatory Mechanism annually; served as Director of BMB Program and PI for its NIH Training Grant

2.

UCSF: Graduate Student Internship for Career Exploration (GSICE) Program. Conceived, launched, secured funding, overseeing direction of post-candidacy internship program in which grad students spend 10 weeks offsite, participating in business, law, communications, policy and other activities that represent potential ways to use their life sciences PhD training

3.

NIH: Conceived and developed implementation for NIH Transformative R-01 grant mechanism and chaired first two rounds of review. Chair, NIH Director’s working group on Enhancing Peer Review; Member, NIH Director’s Working Group on the Biomedical Workforce

4.

National Academy of Sciences/American Academy of Arts & Sciences: Member or chair of two report committees, “Bridges to Independence” and “Alternative Funding Mechanisms” resulting in K99/R00 postdoc/assistant professor transition grant

5.

Cold Spring Harbor Laboratory. Watson School of Biological Sciences. Helped to conceive, launch, achieve accreditation, plan curriculum for novel, rigorous four year graduate program; chair, external advisory committee since founding in 1998.

公共科学政策、科学審査・資金援助、科学関連発表・情報伝達、生物学的研究の一般的理解・支援、科学の社会的影響等に特化した多くの連邦委員会、国家委員会、および州立委員会を主導、またそれらに関与している。

1.

National Academies of Sciences, Engineering and Medicine: Governing Board Executive Committee, Vice Chair NAM Council, Chair Board on Life Sciences, many consensus report committees, e.g., “New Biology for the 21st Century”, “Toward Precision Medicine”.

2.

Coalition for the Life Sciences: Member and chair of alliance of professional organizations working together to foster federal government policies that advance basic biological research and its applications.

3.

NIH: Advisory Committee to the Director, member and chair Center for Scientific Review Advisory Committee, Chair Working Group on Enhancing Peer Review, Director’s Task Force on the Biomedical Workforce, chair Molecular Biology Study Section.

4.

Research!America Board of Directors and Executive Committee; largest not-for-profit public education and advocacy alliance to make research to improve health a higher national priority.

5.

Public Library of Science (PLOS) Board of Directors; open access science publisher.

（自身の研究室の234本の科学論文並びに38本の科学政策論文から最も重要な5本を選択）

1.

Chandler, V.L., Maler, B.A., and Yamamoto, K.R. (1983) DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo. Cell 33(2), 489-499. PMID: 6190571

2.

Diamond, M., Miner, J.N., Yoshinaga, S.K., and Yamamoto, K.R. (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 249, 1266-1272.

3.

Rogatsky, I., Wang, J-C., Derynck, M.K., Nonaka, D., Khodabakhsh, D.B., Haqq, C.M., Darimont, B.D., Garabedian, M.J., and Yamamoto, K.R. (2003) Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 100(24), 13845-13850. PMID: 14617768

4.

Watson, L.C., Kuchenbecker, K.M., Schiller, B.J., Gross, J.D., Pufall, M.A. and Yamamoto, K.R. (2013) The glucocorticoid receptor dimer interface allosterically transmits sequence-specific DNA signals. Nature Struc Mol Biol. 20 (7): 876-83. PMID: 23728292

5.

Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR. (2017) Glucocorticoid receptor control of transcription: precision and plasticity via allostery. Nat Rev Mol Cell Biol. 18(3): 159-174. PMID: 28053348.

（38本の論文および8件の議会証言から選択）

1.

Piller, C., and Yamamoto, K.R. (1988) “Gene Wars: Military Control Over the New Genetic Technologies,” Beech Tree/William Morrow, New York. Hawgood S, Hook-Barnard IG, O’Brien

2.

Alberts, B.M., Ayala, F.J., Botstein, D., Frank, E., Holmes, E.W., Lee, R.D., Macagno, E.R., Marrack, P., Oparil, S., Orkin, S.H., Rubenstein, A.H., Slayman, C.W., Sparling, P.F., Squire, L.R., von Hippel, P.H. and Yamamoto, K.R. (1999) Proposed changes for NIH’s Center for Scientific Review. Science 285, 666-667.

3.

Hawgood, S, O’Brien, TC , Yamamoto KR. (2015) Precision medicine: Beyond the inflection point. Sci Transl Med. Aug 12; 7(300):300ps17.

4.

Yamamoto KR. (2016) The University of the Future, essay contribution to The Power of Ideas http://assets1b.milkeninstitute.org/assets/PillarPage/POI/2016P4C/12YamamotoSingle-Page.pdf

5.

Yamamoto KR, Bassler BL, Cech T, Charo RA, Fishman M, Horvitz HR, Hyman S, Landis S, Marrack P, Tilghman S, Varmas HE, Zerhouni E (2016) A Vision and Pathway for NIH – Recommendations for the New Administration, http://www.nihvp.org/