Professor and Gordon Moore Endowed Chair, Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University

1968-1972

Ph.D., Physics, Kansas State University, Manhattan, Kansas

1964-1968

Professional Engineer, Physics, Colorado School of Mines, Golden, Colorado

2003-2010

Associate Laboratory Director; Biosciences, Division Director, Life Sciences, Lawrence Berkeley National Laboratory

2003-2010

Adjunct Professor, Department of Laboratory Medicine and Radiation Oncology, University of California, San Francisco

1993-2003

Professor, Department of Laboratory Medicine and Radiation Oncology, University of California, San Francisco

1991-1992

Professor in Residence, Department of Laboratory Medicine and Radiation Oncology, University of California, San Francisco

1982-1991

Section Leader, Biomedical Sciences Division, Lawrence Livermore National Laboratory, University of California, Livermore

1972-1991

Biomedical Scientist, Biomedical Sciences Division, Lawrence Livermore National Laboratory, University of California, Livermore

1.

Gray, J.W., Carrano, A.V., Steinmetz, L.L., Van Dilla, M.A., Moore, D.H. II, Mayall, B.H. and Mendelsohn, M.L. (1975) Chromosome measurement and sorting by flow systems. Proc. Natl. Acad. Sci. USA, 72(4):231-1234.

2.

Gray, J.W., Dean, P.N., Fuscoe, J.C., Peters, D.C., Trask, B., van den Engh, G., and Van Dilla, M.A. (1987) High speed chromosome sorting. Science, 238(4825):323-9.

3.

Dolbeare, F., Gratzner, H., Pallavicini, M.G., Gray, J.W. (1983) Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc. Natl. Acad. Sci. USA, 80(18):5573-7; US Patent #4,780,406

4.

Pinkel, D., Landegent, J., Collins, C., Fuscoe, J., Seagraves, R., Lucas, J., and Gray, J.W. (1988) Fluorescence in situ hybridization with human chromosome specific libraries: Detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA, 85(23):9138-42; US patent # 5,447,841, #6,500,612

5.

Kallioniemi, O.-P., Kallioniemi, A., Kurisu, W., Thor, A., Chen, L.-C., Smith, H. S., Waldman, F., Pinkel, D., Gray, J. W. (1992). ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc. Natl. Acad. Sci. USA, 89(12):5321-25. US Patent #5,856,097

6.

Tkachuk, D.C., Westbrook, C.A., Andreeff, M., Donlon, T.A., Cleary, M.L., Suryanarayan, K., Homge, M., Redner, A., Gray, J.W., Pinkel, D. (1990) Detection of bcr-abl fusion in chronic myleogeneous leukemia by in situ hybridization. Science, 250(4980):559-62. US Patent #6,280,929

7.

Kallioniemi, A., Kallioniemi, O.-P., Waldman, F.M., Chen, L.-C., Yu, L.-C., Fung, Y.K., Smith, H.S., Pinkel, D., Gray, J.W. (1992) Detection of retinoblastoma gene copy number in metaphase chromosomes and interphase nuclei by fluorescence in situ hybridization. Cytogenet. Cell Genet., 60(3-4):190-3.

8.

Kallioniemi, A., Kallioniemi, O.-P., Sudar, D., Rutovitz, D., Gray, J., Waldman, F., Pinkel, D. (1992). Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science, 258(5083):818-21; US Patent #5,665,549

9.

Pinkel, D., Segraves, R., Sudar, D., Clark, S., Poole, I., Kowbel, D., Collins, C., Kuo, W.-L., Chen, C., Zhai, Y., Dairkee, S., Lejung, B., Gray, J., and Albertson, D. (1998) High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat. Genet., 20(2):207-11; US Patent #6,210,878

10.

Hodgson, G., Hager, J.H., Volik, S., Hariono, S., Wernick, M., Moore, D., Nowak, N., Albertson, D.G., Pinkel, D., Collins, C., Hanahan, D., Gray, J.W. (2001) Genome scanning with array CGH delineates regional alterations in murine islet carcinomas. Nat. Genet., 29(4):459-64.

11.

Volik, S., Zhao, S., Chin, K., Brebner, J.H., Herndon, D.R., Tao, Q., Kowbel, D., Huang, G., Lapuk, A., Kuo, W.-L., Magrane, G., de Jong, P., Gray, J.W. and Collins. C. (2003) End-sequence profiling: sequence-based analysis of aberrant genomes. Proc. Natl. Acad. Sci. USA, 100(13):7696-701; US Patent #6,785,614

12.

Chin, K., de Solorzano, C.O., Knowles, D., Jones, A., Chou, W., Rodriguez, E.G., Kuo, W.L., Ljung, B.M., Chew, K., Myambo, K., Miranda, M., Krig, S., Garbe, J., Stampfer, M., Yaswen, P., Gray, J.W., Lockett, S.J. (2004) In situ analyses of genome instability in breast cancer. Nat. Genet., 36(9):984-8.

13.

Collisson, E.A., Sadanandam, A., Olson, P., Gibb, W.J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G.E., Jakkula, L., Feiler, H.S., Ko, A.H., Olshen, A.B., Danenberg, K.L., Tempero, M.A., Spellman, P.T., Hanahan, D., Gray, J.W. (2011) Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nature Med., 17:500-503. PMC3755490

14.

Chin, K., DeVries, S., Fridlyand, J., Spellman, P.T., Roydasgupta, R., Kuo, W.-L., Lapuk, A., Neve, R.M., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B.M., Esserman, L., Albertson, D.G., Waldman, F.M., Gray, J.W. (2006) Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell, 10(6):529-41.

15.

Daemen, A., Griffith, O.L., Heiser, L.M., Wang, N.J., Enache, O.M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J.E., Griffith, M., Hur, J.S., Huh, N., Chung, J., Cope, L., Fackler, M.J., Umbricht, C., Sukumar, S., Seth, P. Sukhatme, V.P., Jakkula, L.R., Lu, Y., Mills, G.B., Cho, R.J., Collisson, E.A., van ’t Veer, L.J., Spellman, P.T., Gray, J.W. (2013) Modeling precision treatment of breast cancer. Genome Biol., 14(10):R110. PMC3937590

16.

Heiser, L.M., Sadanandam, A., Kuo, W.L., Benz, S.C., Goldstein, T.C., Ng, S., Gibb, W.J., Wang, N.J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J.I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J.E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K.W., Smith, P.G., Vassilev, L.T., Hennessy, B.T., Greshock, J., Bachman, K.E., Hardwicke, M.A., Park, J.W., Marton, L.J., Wolf, D.M., Collisson, E.A., Neve, R.M., Mills, G.B., Speed, T.P., Feiler, H.S., Wooster, R.F., Haussler, D., Stuart, J.M., Gray, J.W., Spellman, P.T. (2012) Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc. Natl. Acad. Sci. USA., 109(8):2724-9. PMC3286973

17.

Nan X., Collisson, E.A., Lewis, S., Huang, J., Tamguney, T.M., Liphardt, J.T., McCormick, F., Gray, J.W., Chu S. (2013) Proc. Natl. Acad. Sci. U S A. 110:18519-24. Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling. PMC3831949

18.

Nan, X., Tamguney, T.M., Collisson, E.A., Lin, L.J., Pitt, C., Galeas, J., Lewis, S., Gray, J.W., McCormick, F., Chu, S. (2015) Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. Proc. Natl. Acad. Sci. USA, 112(26):7996-8001. PMC4491781