Councilor Joe W. Gray

Councilor Joe W. Gray

Present position

Professor and Gordon Moore Endowed Chair, Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University


Ph.D., Physics, Kansas State University, Manhattan, Kansas
Professional Engineer, Physics, Colorado School of Mines, Golden, Colorado

Professional appointments

Associate Laboratory Director; Biosciences, Division Director, Life Sciences, Lawrence Berkeley National Laboratory
Adjunct Professor, Department of Laboratory Medicine and Radiation Oncology, University of California, San Francisco
Professor, Department of Laboratory Medicine and Radiation Oncology, University of California, San Francisco
Professor in Residence, Department of Laboratory Medicine and Radiation Oncology, University of California, San Francisco
Section Leader, Biomedical Sciences Division, Lawrence Livermore National Laboratory, University of California, Livermore
Biomedical Scientist, Biomedical Sciences Division, Lawrence Livermore National Laboratory, University of California, Livermore

Honors, awards and scholarly activities

Fellow, American Association of Cancer Research Academy Class of 2016
18th Annual Alfred G. Knudson Award Lecture for contributions that have revolutionized the field of cancer genetics, National Cancer Institute, National Institutes of Health
Nieuwland Lecture Series, College of Science, University of Notre Dame
Honorary Doctorate of Engineering, Colorado School of Mines
The Simon M. Shubitz Cancer Prize and Lectureship Award for work in genome science, University of Chicago
Induction into the Lawrence Livermore National Laboratory Entrepreneur’s Hall of Fame (Development of genome analysis technologies)
Elected Member, Institute of Medicine, National Academy of Sciences
Elected Fellow, American Institute for Medical and Biological Engineering
Brinker Award for Scientific Distinction, Susan G. Komen Foundation
Honorary Doctorate, University of Tampere, Tampere, Finland
Distinguished Achievement Award, Colorado School of Mines
Curt Stern Award for outstanding achievement in human cancer genetics research, American Society for Human Genetics
Fellow, American Association for the Advancement of Science
E.O. Lawrence Award for contributions to flow cytometry, cell genetics and cell kinetics, U.S. Department of Energy
Research Award, Radiation Research Society

Selected publications

Gray, J.W., Carrano, A.V., Steinmetz, L.L., Van Dilla, M.A., Moore, D.H. II, Mayall, B.H. and Mendelsohn, M.L. (1975) Chromosome measurement and sorting by flow systems. Proc. Natl. Acad. Sci. USA, 72(4):231-1234.
Gray, J.W., Dean, P.N., Fuscoe, J.C., Peters, D.C., Trask, B., van den Engh, G., and Van Dilla, M.A. (1987) High speed chromosome sorting. Science, 238(4825):323-9.
Dolbeare, F., Gratzner, H., Pallavicini, M.G., Gray, J.W. (1983) Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc. Natl. Acad. Sci. USA, 80(18):5573-7; US Patent #4,780,406
Pinkel, D., Landegent, J., Collins, C., Fuscoe, J., Seagraves, R., Lucas, J., and Gray, J.W. (1988) Fluorescence in situ hybridization with human chromosome specific libraries: Detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA, 85(23):9138-42; US patent # 5,447,841, #6,500,612
Kallioniemi, O.-P., Kallioniemi, A., Kurisu, W., Thor, A., Chen, L.-C., Smith, H. S., Waldman, F., Pinkel, D., Gray, J. W. (1992). ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc. Natl. Acad. Sci. USA, 89(12):5321-25. US Patent #5,856,097
Tkachuk, D.C., Westbrook, C.A., Andreeff, M., Donlon, T.A., Cleary, M.L., Suryanarayan, K., Homge, M., Redner, A., Gray, J.W., Pinkel, D. (1990) Detection of bcr-abl fusion in chronic myleogeneous leukemia by in situ hybridization. Science, 250(4980):559-62. US Patent #6,280,929
Kallioniemi, A., Kallioniemi, O.-P., Waldman, F.M., Chen, L.-C., Yu, L.-C., Fung, Y.K., Smith, H.S., Pinkel, D., Gray, J.W. (1992) Detection of retinoblastoma gene copy number in metaphase chromosomes and interphase nuclei by fluorescence in situ hybridization. Cytogenet. Cell Genet., 60(3-4):190-3.
Kallioniemi, A., Kallioniemi, O.-P., Sudar, D., Rutovitz, D., Gray, J., Waldman, F., Pinkel, D. (1992). Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science, 258(5083):818-21; US Patent #5,665,549
Pinkel, D., Segraves, R., Sudar, D., Clark, S., Poole, I., Kowbel, D., Collins, C., Kuo, W.-L., Chen, C., Zhai, Y., Dairkee, S., Lejung, B., Gray, J., and Albertson, D. (1998) High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat. Genet., 20(2):207-11; US Patent #6,210,878
Hodgson, G., Hager, J.H., Volik, S., Hariono, S., Wernick, M., Moore, D., Nowak, N., Albertson, D.G., Pinkel, D., Collins, C., Hanahan, D., Gray, J.W. (2001) Genome scanning with array CGH delineates regional alterations in murine islet carcinomas. Nat. Genet., 29(4):459-64.
Volik, S., Zhao, S., Chin, K., Brebner, J.H., Herndon, D.R., Tao, Q., Kowbel, D., Huang, G., Lapuk, A., Kuo, W.-L., Magrane, G., de Jong, P., Gray, J.W. and Collins. C. (2003) End-sequence profiling: sequence-based analysis of aberrant genomes. Proc. Natl. Acad. Sci. USA, 100(13):7696-701; US Patent #6,785,614
Chin, K., de Solorzano, C.O., Knowles, D., Jones, A., Chou, W., Rodriguez, E.G., Kuo, W.L., Ljung, B.M., Chew, K., Myambo, K., Miranda, M., Krig, S., Garbe, J., Stampfer, M., Yaswen, P., Gray, J.W., Lockett, S.J. (2004) In situ analyses of genome instability in breast cancer. Nat. Genet., 36(9):984-8.
Collisson, E.A., Sadanandam, A., Olson, P., Gibb, W.J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G.E., Jakkula, L., Feiler, H.S., Ko, A.H., Olshen, A.B., Danenberg, K.L., Tempero, M.A., Spellman, P.T., Hanahan, D., Gray, J.W. (2011) Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nature Med., 17:500-503. PMC3755490
Chin, K., DeVries, S., Fridlyand, J., Spellman, P.T., Roydasgupta, R., Kuo, W.-L., Lapuk, A., Neve, R.M., Qian, Z., Ryder, T., Chen, F., Feiler, H., Tokuyasu, T., Kingsley, C., Dairkee, S., Meng, Z., Chew, K., Pinkel, D., Jain, A., Ljung, B.M., Esserman, L., Albertson, D.G., Waldman, F.M., Gray, J.W. (2006) Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell, 10(6):529-41.
Daemen, A., Griffith, O.L., Heiser, L.M., Wang, N.J., Enache, O.M., Sanborn, Z., Pepin, F., Durinck, S., Korkola, J.E., Griffith, M., Hur, J.S., Huh, N., Chung, J., Cope, L., Fackler, M.J., Umbricht, C., Sukumar, S., Seth, P. Sukhatme, V.P., Jakkula, L.R., Lu, Y., Mills, G.B., Cho, R.J., Collisson, E.A., van ’t Veer, L.J., Spellman, P.T., Gray, J.W. (2013) Modeling precision treatment of breast cancer. Genome Biol., 14(10):R110. PMC3937590
Heiser, L.M., Sadanandam, A., Kuo, W.L., Benz, S.C., Goldstein, T.C., Ng, S., Gibb, W.J., Wang, N.J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J.I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J.E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K.W., Smith, P.G., Vassilev, L.T., Hennessy, B.T., Greshock, J., Bachman, K.E., Hardwicke, M.A., Park, J.W., Marton, L.J., Wolf, D.M., Collisson, E.A., Neve, R.M., Mills, G.B., Speed, T.P., Feiler, H.S., Wooster, R.F., Haussler, D., Stuart, J.M., Gray, J.W., Spellman, P.T. (2012) Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc. Natl. Acad. Sci. USA., 109(8):2724-9. PMC3286973
Nan X., Collisson, E.A., Lewis, S., Huang, J., Tamguney, T.M., Liphardt, J.T., McCormick, F., Gray, J.W., Chu S. (2013) Proc. Natl. Acad. Sci. U S A. 110:18519-24. Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling. PMC3831949
Nan, X., Tamguney, T.M., Collisson, E.A., Lin, L.J., Pitt, C., Galeas, J., Lewis, S., Gray, J.W., McCormick, F., Chu, S. (2015) Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. Proc. Natl. Acad. Sci. USA, 112(26):7996-8001. PMC4491781