Study on cancer of the uterus among A-bomb survivors in the Life Span Study cohort, 1950-2003 (Addendum to RP 8-85)

Summary

Among the Life Span Study (LSS) cohort of the Radiation Effects Research Foundation (RERF), cases of cancer of the uterus (corpus and cervix) that developed during the period between 1957 and 2003 will be ascertained through the Hiroshima and Nagasaki tumor registries, supplemented by uterine cancer cases based on autopsy and surgical pathology records in major medical institutions in both cities and RERF file records and death certificate information from 1950 to 2003. Reported cases will be classified according to the International Classification of Diseases for Oncology (2003) codes and uterine cancers or misdiagnoses of uterine cancers will be reviewed by a panel of pathologists for histological diagnoses, and final diagnoses will be classified according to the World Health Organization’s (WHO’s) Histological Classification of Tumors (2003). Cases of the cervix classified histologically are investigated with polymerase chain reaction for human papillomavirus (HPV) infection and the viral type will be determined. The association between different types of HPV infection and cervical cancer will be investigated. To ascertain precancerous and early cancerous changes of the corpus (e.g., endometrial hyperplasia) as well as the cervix (cervical dysplasia), we will cooperate with medical institutions in Hiroshima and Nagasaki to identify and collect atypical hyperplastic endometrial lesions detected by clinical uterine scraping, or cervical dysplastic lesions identified by vaginal cytology, cervical biopsy or cervical conization among the LSS participants. We will investigate the association between estimated radiation doses (DS02) and cancers of the uterine corpus and cervix by confirmed histological types and sub-types.

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