RP 6-08

Liver stiffness study using elastometer in Hiroshima atomic-bomb survivors


During two examination cycles (four years), we will measure liver stiffness as a marker of liver fibrosis severity with an elastometer for about 3,800 participants of the Adult Health Study (AHS) (including the expanded group of younger survivors) in Hiroshima to examine the relationship between liver stiffness and radiation exposure. In analyzing liver stiffness, we will evaluate possible confounding factors, such as biomarkers related to chronic inflammation, insulin resistance and others, body mass index (BMI), alcohol intake, diet, and hepatitis virus infection. We will also examine the involvement of liver stiffness in prevalence of atherosclerotic disease.