Study of the association between parental radiation exposure and occurrence of de novo germline mutations in their offspring

Summary

Understanding trans-generational genetic effects of radiation exposure is important for radiation protection and for understanding the radiation effects on offspring of victims of atomic bomb and nuclear power plant accidents. Therefore, RERF have a plan to clarify the whole-genome effects of radiation on offspring by conducting whole genome sequencing (WGS) of populations of atomic bomb survivors and their children (i.e., family trios) with next-generation sequencer (NGS). In this study, we will investigate de novo germline mutations and their relationship to paternal and maternal radiation exposure.