田邉 修

所属

バイオサンプル研究センター
分子生物科学部
E-mail: otanabe@rerf.jp

学歴

1985年
広島大学 医学部医学科卒業
1989年
広島大学大学院 医学系研究科修了 医学博士

職歴

広島大学 原爆放射能医学研究所(現 原爆放射線医科学研究所)
  • 1989-1992年臨床第一(内科)研究部門 助手
広島大学 医学部医学科
  • 1992-1995年生化学第二講座 助手
  • 1995-2000年生化学第二講座 講師
米国ノースウェスタン大学
  • 2000-2002年生化学・分子生物学・細胞生物学部門 上級研究員
米国ミシガン大学 医学部
  • 2002-2005年細胞発生生物学部門 研究員
  • 2005-2012年細胞発生生物学部門 研究助教授
東北大学 東北メディカル・メガバンク機構
  • 2012-2018年ゲノム解析部門 教授
放射線影響研究所
  • 2018-2019年バイオサンプル研究センター長、分子生物科学部 主任研究員 兼務
  • 2019-現在主席研究員、バイオサンプル研究センター長、分子生物科学部 兼務

主な論文

  1. Nagasaki M, Kuroki Y, Shibata TF, Katsuoka F, Mimori T, Kawai Y, Minegishi N, Hozawa A, Kuriyama S, Suzuki Y, Kawame H, Nagami F, Takai-Igarashi T, Ogishima S, Kojima K, Misawa K, Tanabe O, Fuse N, Tanaka H, Yaegashi N, Kinoshita K, Kure S, Yasuda J, Yamamoto M: Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Hum Genome Variation 6: 27, 2019.
  2. Yamaguchi-Kabata Y, Yasuda J, Uruno A, Shimokawa K, Koshiba S, Suzuki Y, Fuse N, Kawame H, Tadaka S, Nagasaki M, Kojima K, Katsuoka F, Kumada K, Tanabe O, Tamiya G, Yaegashi N, Kinoshita K, Yamamoto M, Kure S: Tohoku Medical Megabank Project Study Group. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Hum Genet 138: 389-409, 2019.
  3. Yamaguchi-Kabata Y, Yasuda J, Tanabe O, Suzuki Y, Kawame H, Fuse N, Nagasaki M, Kawai Y, Kojima K, Katsuoka F, Saito S, Danjoh I, Motoike IN, Yamashita R, Koshiba S, Saigusa D, Tamiya G, Kure S, Yaegashi N, Kawaguchi Y, Nagami F, Kuriyama S, Sugawara J, Minegishi N, Hozawa A, Ogishima S, Kiyomoto H, Takai-Igarashi T; ToMMo Study Group, Kinoshita K, Yamamoto M: Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. J Hum Genet 63: 213-230, 2018.
  4. Koshiba S, Motoike I, Kojima K, Hasegawa T, Shirota M, Saito T, Saigusa D, Danjoh I, Katsuoka F, Ogishima S, Kawai Y, Yamaguchi-Kabata Y, Sakurai M, Hirano S, Nakata J, Motohashi H, Hozawa A, Kuriyama S, Minegishi N, Nagasaki M, Takai-Igarashi T, Fuse N, Kiyomoto H, Sugawara J, Suzuki Y, Kure S, Yaegashi N, Tanabe O, Kinoshita K, Yasuda J, Yamamoto M: The structural origin of metabolic quantitative diversity. Scientific Reports 6: 31463, 2016.
  5. Saigusa D, Okamura Y, Motoike IN, Katoh Y, Kurosawa Y, Saijyo R, Koshiba S, Yasuda J, Motohashi H, Sugawara J, Tanabe O, Kinoshita K, Yamamoto M: Establishment of protocols for global metabolomics by LC-MS for biomarker discovery. PLoS One 11: e0160555, 2016.
  6. Nagasaki M, Yasuda J, Katsuoka F, Nariai N, Kojima K, Kawai Y, Yamaguchi-Kabata Y, Yokozawa J, Danjoh I, Saito S, Sato Y, Mimori T, Tsuda K, Saito R, Pan X, Nishikawa S, Ito S, Kuroki Y, Tanabe O, Fuse N, Kuriyama S, Kiyomoto H, Hozawa A, Minegishi N, Engel JD, Kinoshita K, Kure S, Yaegashi N, ToMMo Japanese Reference Panel Project, Yamamoto M: Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications 6: 8018, 2015.
  7. Keleku-Lukwete N, Suzuki M, Otsuki A, Tsuchida K, Katayama S, Hayashi M, Naganuma E, Moriguchi T, Tanabe O, Engel JD, Imaizumi M, Yamamoto M: Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. Proc Natl Acad Sci U S A 112: 12169-12174, 2015.
  8. Shi L, Lin YH, Sierant MC, Zhu F, Cui S, Guan Y, Sartor MA, Tanabe O, Lim KC, Engel JD: Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet 23: 4528-4542, 2014.
  9. Shi L, Sierant MC, Gurdziel K, Zhu F, Cui S, Kolodziej KE, Strouboulis J, Guan Y, Tanabe O, Lim KC, Engel JD: Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. PLoS Genet 10: e1004339, 2014.
  10. Shi L, Cui S, Engel JD, Tanabe O: Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nature Medicine 19: 291-294, 2013.
  11. Campbell AD, Cui S, Shi L, Urbonya R, Mathias A, Bradley K, Bonsu KO, Douglas RR, Halford B, Schmidt L, Harro D, Giacherio D, Tanimoto K, Tanabe O, Engel JD: Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A 108(46): 18808-18813, 2011.
  12. Cui S, Kolodziej KE, Obara N, Amaral-Psarris A, Demmers J, Shi L, Engel JD, Grosveld F, Strouboulis J, Tanabe O: Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol 31: 3298-3311, 2011.
  13. Tanabe O, Shen Y, Liu Q, Campbell AD, Kuroha T, Yamamoto M, Engel JD: The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development 21: 2832-2844, 2007.
  14. Tanabe O, McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X, Campbell AD, Chen YT, Chang CS, Yamamoto M, Tanimoto K, Engel JD: Embryonic and fetal β-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J 26: 2295-2306, 2007.

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