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  6. Arikuni Uchimura

Arikuni Uchimura

Affiliation

Department of Molecular Biosciences
E-mail: uchimura@rerf.or.jp

About

Dr. Uchimura joined RERF in April 2017 as a laboratory chief of the Molecular Genetics Laboratory. He studied theoretical population genetics during his master’s degree in graduate school and became interested in de novo germline mutations. Since his PhD course, he has investigated the rates and characteristics of various de novo germline mutations and their health effects on later generations by using animal model. Recent advances in next-generation sequencers have made it possible to analyze de novo mutations on a genome-wide scale. His research group will use state-of-the-art sequencing techniques to analyze the survivors of the atomic bomb and their children, to clarify the molecular features of the biological effects of radiation exposure, especially the genetic effects on the next generation.

Education

2008
Doctor of Philosophy, Graduate School of Frontier Biosciences, The University of Osaka, Japan.
2004
Master of Science, Pharmaceutical Science, The University of Tokyo, Japan.
2002
Bachelor of Arts, Pharmaceutical Science, The University of Tokyo, Japan.

Experience

Radiation Effects Research Foundation, Department of Molecular Biosciences
  • 2024–

    Assistant Department Chief

  • 2017–

    Chief, Laboratory of Molecular Genetics

The University of Osaka, Japan
  • 2011-2017

    Assistant Professor, Graduate School of Frontier Biosciences

  • 2008-2011

    Postdoctoral fellow, Graduate School of Frontier Biosciences

Selected publications

N. Yoshida, D. R. Stewart, A. Uchimura, K.-I. Arita, Y. Bombard, M. Frone, T. Hinoi, K. Kamiya, S. Katamine, J. Kayukawa, K. Kodama, D. T. Miller, K. Miura, K. Muto, F. Nagami, H. Nakagawa, A. Noda, W. Ohishi, O. Tanabe, C. Terao, P. Rajaraman, K. Kato, L. G. Biesecker. Symposium report-ethical and social considerations regarding return of secondary findings in atomic bomb survivors. Carcinogenesis. 2025; 46(3): 1-9.
N. Nakamura, M. Yamada, R. Sakata, W. Ohishi, Y. Tatsukawa, A. Uchimura. Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring. Carcinogenesis. 2025; 46(3): 1-9.
N. Sugo, A. Uchimura, R. Matsumoto, H. Nakayama, S. Fujimoto, S. Mizuno, M. Higuchi, M. Toshishige, Y. Satoh, S. Wakayama, T. Wakayama, T. Yagi. DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons. Proceedings of the National Academy of Sciences of the United States of America. 2025 ; 122 (33) : e2506846122.
K. Yoshida, M. Misumi, K. Hamasaki, S. Kyoizumi, Y. Satoh, T. Tsuruyama, A. Uchimura, Y. Kusunoki. High-dose radiation preferentially induces the clonal expansion of hematopoietic progenitor cells over mature T and B cells in mouse bone marrow. Stem Cell Reports. 2025 ; 20 (3) : 102423.
Y. Matsuda, A. Uchimura, Y. Satoh, N. Kato, M. Toshishige, J. Kajimura, K. Hamasaki, K. Yoshida, T. Hayashi, A. Noda, O. Tanabe. Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2023 ; 120 (15) : e2216550120.
K. Yoshida, Y. Satoh, A. Uchimura, M. Misumi, S. Kyoizumi, M. Taga, Y. Matsuda, A. Noda, Y. Kusunoki. Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation. Scientific Reports. 2022 ; 12(1) : 17276.
A. Uchimura, H. Matsumoto, Y. Satoh, Y. Minakuchi, S. Wakayama, T. Wakayama, M. Higuchi, M. Hashimoto, R. Fukumura, A. Toyoda, Y. Gondo, T. Yagi. Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice. Genome Research. 2022 ; 32 (5) : 945‑955.
Y. Satoh, J. Asakawa, M. Nishimura, T. Kuo, N. Shinkai, H. M. Cullings, Y. Minakuchi, J. Sese, A. Toyoda, Y. Shimada, N. Nakamura, A. Uchimura. Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes. Scientific Reports. 2020 ; 10(1) : 37.
A. Uchimura, M. Higuchi, Y. Minakuchi, M. Ohno, A. Toyoda, A. Fujiyama, I. Miura, S. Wakana, J. Nishino, T. Yagi. Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice. Genome Research. 2015 ; 25 (8) : 1125–1134.
A. Uchimura, Y. Hidaka, T. Hirabayashi, M. Hirabayashi, T. Yagi. DNA polymerase delta is required for early mammalian embryogenesis. PLOS ONE. 2009 ; 4(1) : e4184.

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