Arikuni Uchimura


Department of Molecular Biosciences


Dr. Uchimura joined RERF in April 2017 as a laboratory chief of the Molecular Genetics Laboratory. He studied theoretical population genetics during his master’s degree in graduate school and became interested in de novo germline mutations. Since his PhD course, he has investigated the rates and characteristics of various de novo germline mutations and their health effects on later generations by using animal model. Recent advances in next-generation sequencers have made it possible to analyze de novo mutations on a genome-wide scale. His research group will use state-of-the-art sequencing techniques to analyze the survivors of the atomic bomb and their children, to clarify the molecular features of the biological effects of radiation exposure, especially the genetic effects on the next generation.


Doctor of Philosophy, Graduate School of Frontier Biosciences, Osaka University, Japan.
Master of Science, Pharmaceutical Science, University of Tokyo, Japan.
Bachelor of Arts, Pharmaceutical Science, University of Tokyo, Japan.


Radiation Effects Research Foundation, Department of Molecular Biosciences
  • 2017-

    Chief, Laboratory of Molecular Genetics

Osaka University, Japan
  • 2011-2017

    Assistant Professor, Graduate School of Frontier Biosciences

  • 2008-2011

    Postdoctoral fellow, Graduate School of Frontier Biosciences

Selected publications

Y. Satoh, A. Uchimura. Analysis of transgenerational effects of radiation exposure using whole genome sequencing (in Japanese). Isotope News. 2021; 773: 44-46.
Y. Satoh, J. Asakawa, M. Nishimura, T. Kuo, N. Shinkai, H.M. Cullings, Y. Minakuchi, J. Sese, A. Toyoda, Y. Shimada, N. Nakamura, A. Uchimura. Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes. Scientific Rep. 2020; 10(1): 37.
A. Uchimura, M. Higuchi, T. Yagi. Analysis of mammalian germline mutation’s effects on future generations by using mutation accumulation experiment (in Japanese). Radiation Biology Research Communications. 2017; 52(4): 402-415.
A. Uchimura, M. Higuchi, Y. Minakuchi, M. Ohno, A. Toyoda, A. Fujiyama, I. Miura, S. Wakana, J. Nishino, T. Yagi. Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice. Genome Research. 2015; 25(8): 1125-1134.
H. Tsukano, M. Horie, T. Bo, A. Uchimura, R. Hishida, M. Kudoh, K. Takahashi, H. Takebayashi, and K. Shibuki. Delineation of a frequency-organized region isolated from the mouse primary auditory cortex. Journal of Neurophysiology. 2015; 113 (7): 2900-2920.
A. Uchimura, T. Yagi. Brain evolution from population genetics (in Japanese). Clinical Neuroscience 2015; 33(8): 909-911.
R. Kaneko, M. Abe, T. Hirabayashi, A. Uchimura, K. Sakimura, Y. Yanagawa and T. Yagi. Expansion of stochastic expression repertoire by tandem duplication in mouse Protocadherin-α cluster. Scientific Rep. 2014; 4, 6263.
Y. Noguchi, T. Hirabayashi, S. Katori, Y. Kawamura, M. Sanbo, M. Hirabayashi, H. Kiyonari, K. Nakao, A. Uchimura, and T. Yagi. Total Expression and Dual Gene-regulatory Mechanisms Maintained in Deletions and Duplications of the Protocadherin-α Cluster. The Journal of Biological Chemistry. 2009; 284(46): 32002-14.
A. Uchimura, Y. Hidaka, T. Hirabayashi, M. Hirabayashi and T. Yagi. DNA Polymerase δ Is Required for Early Mammalian Embryogenesis. PLoS ONE. 2009; 4(1): e4184.