Yoichro Kusunoki

Affiliation

Department of Molecular Biosciences
E-mail: ykusunok@rerf.or.jp

About

Dr. Kusunoki has been devoting to studies of hematopoiesis and immunity in A-bomb survivors since his joining the Immunology Laboratory at RERF in 1986. Accumulating evidence from his studies involves perturbed hematopoiesis and accelerated immunological aging in the survivors. His current research interests include clonal hematopoiesis due to radiation exposure, for understanding mechanisms of radiation-associated non-cancer diseases such as cardiovascular diseases. Using immunological data obtained in his previous studies, he is also designing studies to follow-up development of cancer and noncancer diseases among participants in the Adult Health Study, which may provide implication of radiation-associated immunological change in elevated disease risks among A-bomb survivors. Dr. Kusunoki was born in Hiroshima City and graduated from Hiroshima Kanon High School that suffered many victims of the A-bomb when it was the Second Hiroshima Prefectural Junior High School in 1945.

Education

1986
Doctor of Philosophy, Hematology, Hiroshima University, Graduate School of Medicine, Hiroshima, Japan
1979
Master of Science, Medicinal Chemistry, Okayama University, Graduate School of Pharmacy, Okayama, Japan
1977
Bachelor of Pharmacy, Gifu Pharmaceutical University, Gifu, Japan

Experience

Radiation Effects Research Foundation
  • 2018-

    Assistant Chief, Department of Molecular Biosciences

  • 2015-2018

    Chief, Department of Molecular Biosciences

  • 2011-2015

    Chief, Department of Radiobiology/Molecular Epidemiology

  • 2009–2011

    Acting Chief, Department of Radiobiology/Molecular Epidemiology

  • 2004-2008

    Assistant Chief, Department of Radiobiology/Molecular Epidemiology

  • 2003–2004

    Chief, Immunology Laboratory, Department of Radiobiology

  • 1986–2003

    Research Scientist, Department of Radiobiology

Fred Hutchinson Cancer Research Center, Seatle, Washington, USA
  • 1993-1995

    Visiting Scientist, Immunogenetics Program

Selected publications

Yoshida K, French B, Yoshida N, Hida A, Ohishi C, Kusunoki Y. Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: The Adult Health Study of atomic-bomb survivors. Br J Haematol. 2019; 185: 107-115.
Yoshida K, Cologne JB, Cordova KA, Misumi M, Yamaoka M, Kyoizumi S, Hayashi T, Robins H, Kusunoki Y. Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors. Exp Gerontol. 2017; 96: 29-37.
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR, Kusunoki Y. Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors. J Immunol. 2014; 192: 5749-5760.
Kusunoki Y, Yamaoka M, Kubo Y, Hayashi T, Kasagai F, Douple EB, Nakachi K. T-cell immunosenescence and inflammatory response in atomic-bomb survivors. Radiat Res. 2010; 174: 870–876.
Kusunoki Y, Hayashi T. Long-lasting alterations of the immune system by ionizing radiation exposure: Implications for disease development among atomic bomb survivors. Int J Radiat Biol. 2008; 84: 1-14.
Kusunoki Y, Yamaoka M, Kasagi F, Hayashi T, MacPhee DG, Kyoizumi S. Long-lasting changes in the T-cell receptor V beta repertoires of CD4 memory T-cell populations in the peripheral blood of radiation-exposed people. Br J Haematol. 2003; 122: 975-984.
Kusunoki Y, Kyoizumi S, Honma M, Kubo Y, Ohnishi H, Hayashi T, Seyama T. NK-mediated elimination of mutant lymphocytes that have lost expression of MHC class I molecules. J Immunol. 2000; 165: 3555-3563.
Kusunoki Y, Kyoizumi S, Hirai Y, Suzuki T, Nakashima E, Kodama K, Seyama T. Flow cytometry measurements of subsets of T, B and NK cells in peripheral blood lymphocytes of atomic bomb survivors. Radiat Res. 1998; 150: 227-236.
Kusunoki Y, Kodama Y, Hirai Y, Kyoizumi S, Nakamura N, Akiyama M. Cytogenetic and immunologic identification of clonal expansion of stem cells into T and B lymphocytes in one atomic-bomb survivor. Blood. 1995; 86: 2106-2112.
Kusunoki Y, Hirai Y, Hayashi T, Kyoizumi S, Takahashi K, Morishita Y, Kodama Y, Akiyama M. Frequent occurrence of in vivo clonal expansion of CD4 CD8 T cells bearing T cell receptor αβ chains in adult humans. Eur J Immunol. 1993; 23: 2735 2739.

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