Waka Ohishi

Affiliation

Department of Clinical Studies
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About

Dr. Ohishi was hired as a research scientist of the Department of Clinical Studies in April 2004 and has been engaged in long-term follow-up cohort studies of A-bomb survivors and their children through health examinations. Previously, she worked in the Department of Gastroenterology, Hiroshima University Hospital, and the Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, where she was involved in treatment and research of digestive diseases. A PCR method for early detection of drug-resistant hepatitis B virus she developed at Hiroshima University was useful for selecting treatment methods and elucidating mechanisms of virus replication. Her current research interest is to understand pathophysiology associated with radiation carcinogenesis by identifying risk factors for hepatocellular carcinoma and determining factors and biomarkers that influence radiation risk. Also, to determine whether radiation exposure is involved in the increased risk of liver diseases through hepatitis virus, liver fibrosis, insulin resistance, inflammation, etc.

Education

2004
Ph.D. (Medical Science) Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University
1992
M.D. School of Medicine, Hiroshima University

Experience

2018-
Office Chief, Emergency Workers Health Study Office, Department of Clinical Studies, Radiation Effects Research Foundation
2014-
Chief, Department of Clinical Studies, Radiation Effects Research Foundation
2011-2014
Assistant Department Chief, Department of Clinical Studies, Radiation Effects Research Foundation
2008-
Senior Scientist, Department of Clinical Studies, Radiation Effects Research Foundation
2005-2020
Division Chief, Division of Clinical Laboratories, Department of Clinical Studies, Radiation Effects Research Foundation
2004-2008
Research Scientist, Department of Clinical Studies, Radiation Effects Research Foundation
2002-2004
Physician, Department of Gastroenterology, Hiroshima University Hospital
1997-2002
Research student, Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University
1994-1997
Physician, Department of Gastroenterology, Hiroshima-Nishi Medical Center
1993
Resident, Department of Internal Medicine, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital
1992-1994
Resident, Department of Internal Medicine, Hiroshima University Hospital

Selected publications

Ueda K, Ohishi W, Cullings H, Fujiwara S, Suzuki G, Hayashi T, Mitsui F, Hida A, Ozasa K, Ito M, Chayama K, Tahara E. Modifying effect of chronic atrophic gastritis on radiation risk for noncardia gastric cancer according to histological type. Radiat Res. 2020; 194(2): 180-7.
Ozasa K, Cullings HM, Ohishi W, Hida A, Grant EJ. Epidemiological studies of atomic bomb radiation at the Radiation Effects Research Foundation. Int J Radiat Biol. 2019; 95(7): 879-91.
Imaizumi M, Ohishi W, Nakashima E, Sera N, Neriishi K, Yamada M, Tatsukawa Y, Takahashi I, Fujiwara S, Sugino K, Ando T, Usa T, Kawakami A, Akahoshi M, Hida A. Thyroid dysfunction and autoimmune thyroid diseases among atomic-bomb survivors exposed in childhood. J Clin Endocrinol Metab. 2017; 102(7): 2516-24.
Imaizumi M, Ohishi W, Nakashima E, Sera N, Neriishi K, Yamada M, Tatsukawa Y, Takahashi I, Fujiwara S, Sugino K, Ando T, Usa T, Kawakami A, Akahoshi M, Hida A. Association of radiation dose with prevalence of thyroid nodules among atomic bomb survivors exposed in childhood (2007-2011). JAMA Intern Med. 2015; 175(2): 228-36.
Ohishi W, Cologne JB, Fujiwara S, Suzuki G, Hayashi T, Niwa Y, Akahoshi M, Ueda K, Tsuge M, Chayama K. Serum interleukin-6 associated with hepatocellular carcinoma risk: A nested case-control study. Int J Cancer. 2014; 134(1): 154-63.
Tatsukawa Y, Cologne JB, Hsu WL, Yamada M, Ohishi W, Hida A, Furukawa K, Takahashi N, Nakamura N, Suyama A, Ozasa K, Akahoshi M, Fujiwara S, Shore RE. Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: A clinical health study. J Radiol Prot. 2013; 33(2): 281-93.
Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Tsuge M, Chayama K. Impact of radiation and hepatitis virus infection on risk of hepatocellular carcinoma. Hepatology. 2011; 53(4): 1237-45.
Ohishi W, Fujiwara S, Cologne JB, Suzuki G, Akahoshi M, Nishi N, Takahashi I, Chayama K. Risk factors for hepatocellular carcinoma in a Japanese population: A nested case-control study. Cancer Epidemiol Biomar Prev. 2008; 17(4): 846-54.
Ohishi W, Fujiwara S, Suzuki G, Kishi T, Sora M, Matsuura S, Hakoda M, Tatsukawa Y, Yamada M, Chayama K. Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses. J Clin Microbiol. 2006; 44(12): 4593-5.
Ohishi W, Shirakawa H, Kawakami Y, Kimura S, Kamiyasu M, Tazuma S, Nakanishi T, Chayama K. Identification of rare polymerase variants of hepatitis B virus using two-stage PCR with peptide nucleic acid clamping. J Med Virol. 2004; 72(4): 558-65.

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