Kengo Yoshida
Affiliation
Department of Molecular Biosciences
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About
Dr. Yoshida is a Chief of Immunology Laboratory at RERF. A major aim of his research is to understand the molecular bases underlying health effects of radiation exposure on the hematopoietic and immune systems with the hypothesis that radiation exposure may accelerate the aging process, consequently elevating risks of age-associated diseases. Specifically, he examines radiation effects on clonal hematopoiesis with somatic mutations in A-bomb survivors.
Education
- 2006
- Doctor of Philosophy, Evolutional Biology/Population Genetics, National Institute of Genetics, Mishima, Japan.
- 2003
- Master of Science, Cellular Biology, Hiroshima University, Hiroshima, Japan.
- 2001
- Bachelor of Science, Molecular Biology, Hiroshima University, Hiroshima, Japan
Experience
- Radiation Effects Research Foundation, Department of Molecular Biosciences
-
- 2024-
Assistant Department Chief
- 2018-
Chief, Immunology Laboratory
- 2006-2018
Research Scientist, Immunology Laboratory
- 2024-
- Hiroshima University, Graduate School of Biomedical and Health Sciences
-
- 2024-
Visiting Professor
- 2021-2024
Visiting Associate Professor
- 2024-
- National Institute of Genetics, Center for Information Biology
-
- 2003-2006
Research Assistant
- 2003-2006
Selected publications
- Yoshida K, Misumi M, Yamaoka M, Kyoizumi S, Ohishi W, Sugiyama H, Hayashi T, and Kusunoki Y. Naive CD4 T cells highly expressing the inflammatory chemokine receptor CXCR3 increase with age and radiation exposure in atomic bomb survivors. Radiation Research 2024; 201 (1): 71-6.
- Mika J, Yoshida K, Kusunoki Y, Candeias S, and Polanska J. Sex- and age-specific aspects of human peripheral T-cell dynamics. Frontiers in Immunology 2023; 14: 1224304.
- Yoshida K, Satoh Y, Uchimura A, Misumi M, Kyoizumi S, Taga M, Matsuda Y, Noda A, and Kusunoki Y. Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation. Scientific Reports 2022; 12 (1): 17276.
- Yoshida K, Misumi M, Kusunoki Y, and Yamada M. Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic-bomb survivors. British Journal of Haematology 2021; 193 (2): 406-9.
- Yoshida K, French B, Yoshida N, Hida A, Ohishi W, and Kusunoki Y. Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: The Adult Health Study of atomic-bomb survivors. British Journal of Haematology 2019; 185: 107-15.
- Yoshida K, Cologne JB, Cordova K, Misumi M, Yamaoka M, Kyoizumi S, Hayashi T, Robins H, and Kusunoki Y. Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors. Experimental Gerontology 2017; 96: 29-37.
- Yoshida K, Misumi M, Kubo Y, Yamaoka M, Kyoizumi S, Ohishi W, Hayashi T, and Kusunoki Y. Long-term Effects of Radiation Exposure and Metabolic Status on Telomere Length of Peripheral Blood T Cells in Atomic bomb Survivors. Radiation Research 2016; 186 (4): 367-76.
- Yoshida K, Nakashima E, Kyoizumi S, Hakoda M, Hayashi T, Hida A, Ohishi W, and Kusunoki Y. Metabolic profile as a potential modifier of long-term radiation effects on peripheral lymphocyte subsets in atomic bomb survivors. Radiation Research 2016; 186 (3): 275-82.
- Yoshida K, Kusunoki Y, Cologne JB, Kyoizumi S, Maki M, Nakachi K, and Hayashi T. Radiation dose-response of glycophorin A somatic mutation in erythrocytes associated with gene polymorphisms of p53 binding protein 1. Mutation Research 2013; 755 (1): 49-54.
- Yoshida K, Fujisawa T, Hwang JS, Ikeo K, and Gojobori T. Degeneration after sexual differentiation in hydra and its relevance to the evolution of aging. Gene 2006; 385: 64-70.