Yukiko Matsuda

Affiliation

Department of Molecular Biosciences (Concurrently assigned to the Biosample Research Center)
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About

She joined RERF as a research scientist in November 2019. Her current research interest is radiation-induced somatic mutagenesis and oncogenesis. Using mouse models, she is studying radiation-induced somatic mutations in hematopoietic stem cells, and whether or not oxidative stress responses play any role in protection against radiation-induced mutagenesis and oncogenesis. Before joining RERF, she had been working on molecular genetic and pathophysiological features of neurodegenerative diseases in the Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University.

Education

1999
Doctor of Medicine, Osaka University
1995
Master of Medical Science, Osaka University
1993
Bachelor of Engineering, Osaka University

Experience

Radiation Effects Research Foundation
  • 2019-

    Research Scientist, Department of Molecular Biosciences

Hiroshima University
  • 2018-

    Research Associate, Department of Epidemiology, Research Institute for Radiation Biology and Medicine

  • 2015-2018

    Postdoctoral Research Fellow of JSPS, Department of Epidemiology, Research Institute for Radiation Biology and Medicine

  • 2014-2015

    Assistant Professor, Department of Epidemiology, Research Institute for Radiation Biology and Medicine

Selected publications

Matsuoka T, Yamasaki M, Abe M, Matsuda Y, Morino H, Kawakami H, Sakimura K, Watanabe M, Hashimoto K. Kv11 (ether-à-go-go-related gene) voltage-dependent K+ channels promote resonance and oscillation of subthreshold membrane potentials. J Physiol. 2021 Jan; 599(2):547-569.
Hara N, Morino H, Matsuda Y, Satoh K, Hashimoto K, Maruyama H, Kawakami H. Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel Cav3.1 caused by a mutation responsible for spinocerebellar ataxia. Mol Brain. 2020 Nov 26; 13(1):163.
Kume K, Takata T, Morino H, Matsuda Y, Ohsawa R, Tada Y, Kurashige T, Kawakami H. The first Japanese case of primary familial brain calcification caused by an MYORG variant. J Hum Genet. 2020 Oct; 65(10):917-920.
Kume K, Morino H, Miyamoto R, Matsuda Y, Ohsawa R, Kanaya Y, Tada Y, Kurashige T, Kawakami H. Middle-age-onset cerebellar ataxia caused by a homozygous TWNK variant: a case report. BMC Med Genet. 2020 Mar 31; 21(1):68.
Matsuda Y, Morino H, Miyamoto R, Kurashige T, Kume K, Mizuno N, Kanaya Y, Tada Y, Ohsawa R, Yokota K, Shimozawa N, Maruyama H, Kawakami H. A biallelic mutation of HSD17B4 induces middle-age-onset spinocerebellar ataxia. Neurol Genet. 2020 Jan 16 ;6(1):e396.
Kurashige T, Morino H, Matsuda Y, Mukai T, Murano T, Toko M, Kume K, Ohsawa R, Torii T, Tokinobu H, Maruyama H, Kawakami H. Retinitis pigmentosa prior to familial ALS caused by a homozygous cilia and flagella-associated protein 410 mutation. J Neurol Neurosurg Psychiatry. 2020 Feb; 91(2):220-222.
Tada Y, Kume K, Matsuda Y, Kurashige T, Kanaya Y, Ohsawa R, Morino H, Tabu H, Kaneko S, Suenaga T, Kakizuka A, Kawakami H. Genetics screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia. J Hum Genet. 2019 Apr; 65(4):363-369.
Kume K, Morino H, Komure O, Matsuda Y, Ohsawa R, Kurashige T, Kanaya Y, Tada Y, Kawakami H. C-terminal mutations in SYNE1 are associated with motor neuron disease in patients with SCAR8. J Neurol Sci. 2019 Jul 15; 402, 118-120.
Morino H, Matsuda Y, Muguruma K, Miyamoto R, Ohsawa R, Ohtake T, Otobe R, Watanabe M, Maruyama H, Hashimoto K, Kawakami H. A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia. Mol Brain. 2015 Dec 29; 8:89.
Morino H, Pierce SB, Matsuda Y, Walsh T, Ohsawa R, Newby M, Hiraki-Kamon K, Kuramochi M, Lee MK, Klevit RE, Martin A, Maruyama H, King MC, and Kawakami H. Mutations in Twinkle primase-helicase cause Perrault syndrome with neurologic features. Neurology. 2014 Nov 25; (83(22)),2054-2061.

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