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  6. Richard Sposto

Richard Sposto

Affiliation

Department of Statistics
E-mail: rsposto@rerf.or.jp

About

Dr. Sposto assumed the position of Chief of the RERF Department of Statistics in September 2019. He previously was Director of Biostatistics/Bioinformatics for the Children’s Center for Cancer and Blood Diseases, Division of Hematology/Oncology/BMT, Children’s Hospital Los Angeles (CHLA) and Co-Director of the Biostatistics Core of the USC Norris Comprehensive Cancer Center, and a faculty member in the Department of Preventive Medicine, Keck School of Medicine at the University of Southern California. He has been involved in medical research since 1981. Between 1988 and 1992 he was a Research Scientist in the Department of Statistics at RERF.

Education

1981
Doctor of Philosophy, Biostatistics, University of California Los Angeles, Los Angeles, California, USA.
1978
Master of Science, Biostatistics, University of California Los Angeles, Los Angeles, California, USA.
1974
Bachelor of Arts, Mathematics, University of California, Los Angeles, Los Angeles, California, USA.

Experience

Radiation Effects Research Foundation, Department of Statistics
  • 2019-

    Senior Scientist, and Chief, Department of Statistics

  • 1988-1992

    Research Scientist, Department of Statistics

University of Southern California, Los Angeles, California, USA
  • 2019-

    Professor Emeritus of Research Preventive Medicine, Keck School of Medicine of USC

  • 2005-2019

    Professor of Research of Preventive Medicine and Pediatrics (CHLA), Keck School of Medicine of USC

  • 1994-2005

    Associate Professor of Research of Preventive Medicine, Keck School of Medicine of USC

  • 1981-1988

    Assistant Professor of Research of Preventive Medicine, USC School of Medicine

  • 2004-2019

    Director Biostatistics/Bioinformatics, Department of Hematology/Oncology/BMT, Children’s Hospital Los Angeles, Los Angeles, CA

  • 2002-2004

    Group Statistician, Children’s Oncology Group

  • 1994-2002

    Biostatistician, Children’s Cancer Group/Children’s Oncology Group

  • 1981-1988

    Biostatistician, Children’s Cancer Study Group

The EMMES Corporation, Potomac, Maryland, USA
  • 1992-1994

    Statistician, Co-PI Aids Vaccine Evaluation Group

Selected publications

Sposto, R., Bias in Low Dose Risk Estimation due to the Constant RBE Assumption in RERF Studies. Radiat Res, 2026.
Shimizu, S., T. Sato, S. Funamoto, R. Sposto, H.M. Cullings, A. Endo, S.D. Egbert, and M. Kai, Calculations of mean quality factors and their implications for organ-specific Relative Biological Effectiveness(RBE) in analysis of radiation-related risk in the atomic bomb survivors. Radiat Res, 2025. 203(3): p. 155-62.
Cologne, J.B., M. Misumi, H. Lindner, Z. Liu, and R. Sposto, Recent evolution of risk analyses in atomic-bomb survivor studies: New methods and applications. Carcinogenesis, 2025. 46(3): p. bgaf043.
Sposto, R. and H.M. Cullings, The Use of Joint Models in Analysis of Aggregate Endpoints in RERF Cohort Studies. Radiat Res, 2024.
Sposto, R., H. Sugiyama, T. Tsuruyama, and A.V. Brenner, Effect of radiation exposure on survival after first solid cancer diagnosis in A-bomb survivors. Cancer Epidemiol, 2023. 83: p. 102341.
Sposto, R., K.A. Cordova, K. Hamasaki, N. Nakamura, A. Noda, and Y. Kodama, The Association of Radiation Exposure with Stable Chromosome Aberrations in Atomic Bomb Survivors Based on DS02R1 Dosimetry and FISH Methods. Radiat Res, 2023. 199(2): p. 170-181.
Sposto, R., T.H.M. Keegan, C. Vigen, M.L. Kwan, L. Bernstein, E.M. John, I. Cheng, J. Yang, J. Koo, A.W. Kurian, B.J. Caan, Y.N. Lu, K.R. Monroe, S. Shariff-Marco, S.L. Gomez, and A.H. Wu. The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality. Cancer Epidemiology Biomarkers & Prevention. 2016; 25(7): 1064-1072.
Sposto, R., W.B. London, and T.A. Alonzo. Criteria for optimizing prognostic risk groups in pediatric cancer: analysis of data from the Children’s Oncology Group. Journal of Clinical Oncology. 2007; 25(15): 2070-77.
Sposto, R. Cure model analysis in cancer: An application to data from the Children’s Cancer Group. Statistics in Medicine. 2002; 21: 293-312.
Sposto, R. and D.O. Stram. A strategic view of randomized trial design in low-incidence paediatric cancer. Statistics in Medicine. 1999; 18(10): 1183-97.
Sposto, R., D.L. Preston, Y. Shimizu, and K. Mabuchi. The effect of diagnostic misclassification on non-cancer and cancer mortality dose response in A-bomb survivors. Biometrics. 1992; 48(2): 605-17.
Sposto, R., D.O. Stram, and A.A. Awa. An estimate of the magnitude of random errors in the DS86 dosimetry from data on chromosome aberrations and severe epilation. Radiation Research. 1991; 128(2): 157-69.

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