Richard Sposto
Affiliation
Department of Statistics
E-mail: rsposto@rerf.or.jp
E-mail: rsposto@rerf.or.jp
About
Dr. Sposto assumed the position of Chief of the Department of Statistics in September 2019. Dr. Sposto previously was Director of Biostatistics/Bioinformatics for the Children’s Center for Cancer and Blood Diseases, Division of Hematology/Oncology/BMT, Children’s Hospital Los Angeles (CHLA) and Co-Director of the Biostatistics Core of the USC Norris Comprehensive Cancer Center, and a faculty member in the Department of Preventive Medicine, Keck School of Medicine at the University of Southern California. He has been involved in medical (primarily oncology) research since 1981. Between 1988 and 1992 he was a Research Scientist in the Department of Statistics at RERF. His current research interests include optimal study design for the RERF study of the genetics effects of radiation in offspring of atomic bomb survivors, understanding the relationship between cancer incidence and cancer mortality dose response in the context of contemporary treatment for cancer, and flexible modelling of the radiation dose response in the low dose range.
Education
- 1981
- Doctor of Philosophy, Biostatistics, University of California Los Angeles, Los Angeles, California, USA.
- 1978
- Master of Science, Biostatistics, University of California Los Angeles, Los Angeles, California, USA.
- 1974
- Bachelor of Arts, Mathematics, University of California, Los Angeles, Los Angeles, California, USA.
Experience
- Radiation Effects Research Foundation, Department of Statistics
-
- 2019-Senior Scientist, and Chief, Department of Statistics
- 1988-1992Research Scientist, Department of Statistics
- University of Southern California, Los Angeles, California, USA
-
- 2019-
Professor Emeritus of Research Preventive Medicine, Keck School of Medicine of USC
- 2005-2019
Professor of Research of Preventive Medicine and Pediatrics (CHLA), Keck School of Medicine of USC
- 1994-2005
Associate Professor of Research of Preventive Medicine, Keck School of Medicine of USC
- 1981-1988
Assistant Professor of Research of Preventive Medicine, USC School of Medicine of USC
- 2004-2019
Director Biostatistics/Bioinformatics, Department of Hematology/Oncology/BMT, Children’s Hospital Los Angeles, Los Angeles, CA
- 2002-2004
Group Statistician, Children’s Oncology Group
- 1994-2002
Biostatistician, Children’s Cancer Group/Children’s Oncology Group
- 1981-1988
Biostatistician, Children’s Cancer Study Group
- 2019-
- The EMMES Corporation, Potomac, Maryland, USA
-
- 1992-1994Statistician, Co-PI Aids Vaccine Evaluation Group
Selected publications
- Ji, L., L.M. McShane, M. Krailo, and R. Sposto. Bias in retrospective analyses of biomarker effect using data from an outcome-adaptive randomized trial. Clin Trials. 2019; 16(6): 599-609.
- Ji, L., J.P. Lewinger, M. Krailo, S. Groshen, D.V. Conti, S. Asgharzadeh, and R. Sposto. Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method. Pharm Stat. 2019; 18(6): 659-670.
- Maruffi, M., R. Sposto, M.J. Oberley, L. Kysh, and E. Orgel. Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis. Leukemia. 2018; 32(7): 1515-1528.
- Sposto, R., T.H.M. Keegan, C. Vigen, M.L. Kwan, L. Bernstein, E.M. John, I. Cheng, J. Yang, J. Koo, A.W. Kurian, B.J. Caan, Y.N. Lu, K.R. Monroe, S. Shariff-Marco, S.L. Gomez, and A.H. Wu. The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality. Cancer Epidemiology Biomarkers & Prevention. 2016; 25(7): 1064-1072.
- Sposto, R. and P.S. Gaynon. An adjustment for patient heterogeneity in the design of two-stage phase II trials. Statistics in Medicine. 2009; 28(20): 2566 – 2579.
- Sposto, R., W.B. London, and T.A. Alonzo. Criteria for optimizing prognostic risk groups in pediatric cancer: analysis of data from the Children’s Oncology Group. Journal of Clinical Oncology. 2007; 25(15): 2070-77.
- Sposto, R. Cure model analysis in cancer: An application to data from the Children’s Cancer Group. Statistics in Medicine. 2002; 21: 293-312.
- Sposto, R. and D.O. Stram. A strategic view of randomized trial design in low-incidence paediatric cancer. Statistics in Medicine. 1999; 18(10): 1183-97.
- Sposto, R., D.L. Preston, Y. Shimizu, and K. Mabuchi. The effect of diagnostic misclassification on non-cancer and cancer mortality dose response in A-bomb survivors. Biometrics. 1992; 48(2): 605-17.
- Sposto, R., D.O. Stram, and A.A. Awa. An estimate of the magnitude of random errors in the DS86 dosimetry from data on chromosome aberrations and severe epilation. Radiation Research. 1991; 128(2): 157-69.