Richard Sposto


Department of Statistics


Dr. Sposto assumed the position of Chief of the Department of Statistics in September 2019. Dr. Sposto previously was Director of Biostatistics/Bioinformatics for the Children’s Center for Cancer and Blood Diseases, Division of Hematology/Oncology/BMT, Children’s Hospital Los Angeles (CHLA) and Co-Director of the Biostatistics Core of the USC Norris Comprehensive Cancer Center, and a faculty member in the Department of Preventive Medicine, Keck School of Medicine at the University of Southern California. He has been involved in medical (primarily oncology) research since 1981. Between 1988 and 1992 he was a Research Scientist in the Department of Statistics at RERF. His current research interests include optimal study design for the RERF study of the genetics effects of radiation in offspring of atomic bomb survivors, understanding the relationship between cancer incidence and cancer mortality dose response in the context of contemporary treatment for cancer, and flexible modelling of the radiation dose response in the low dose range.


Doctor of Philosophy, Biostatistics, University of California Los Angeles, Los Angeles, California, USA.
Master of Science, Biostatistics, University of California Los Angeles, Los Angeles, California, USA.
Bachelor of Arts, Mathematics, University of California, Los Angeles, Los Angeles, California, USA.


Radiation Effects Research Foundation, Department of Statistics
  • 2019-

    Senior Scientist, and Chief, Department of Statistics

  • 1988-1992

    Research Scientist, Department of Statistics

University of Southern California, Los Angeles, California, USA
  • 2019-

    Professor Emeritus of Research Preventive Medicine, Keck School of Medicine of USC

  • 2005-2019

    Professor of Research of Preventive Medicine and Pediatrics (CHLA), Keck School of Medicine of USC

  • 1994-2005

    Associate Professor of Research of Preventive Medicine, Keck School of Medicine of USC

  • 1981-1988

    Assistant Professor of Research of Preventive Medicine, USC School of Medicine of USC

  • 2004-2019

    Director Biostatistics/Bioinformatics, Department of Hematology/Oncology/BMT, Children’s Hospital Los Angeles, Los Angeles, CA

  • 2002-2004

    Group Statistician, Children’s Oncology Group

  • 1994-2002

    Biostatistician, Children’s Cancer Group/Children’s Oncology Group

  • 1981-1988

    Biostatistician, Children’s Cancer Study Group

The EMMES Corporation, Potomac, Maryland, USA
  • 1992-1994

    Statistician, Co-PI Aids Vaccine Evaluation Group

Selected publications

Sposto, R. and H.M. Cullings, The Use of Joint Models in Analysis of Aggregate Endpoints in RERF Cohort Studies. Radiat Res, 2024.
Sposto, R., H. Sugiyama, T. Tsuruyama, and A.V. Brenner, Effect of radiation exposure on survival after first solid cancer diagnosis in A-bomb survivors. Cancer Epidemiol, 2023. 83: p. 102341.
Sposto, R., K.A. Cordova, K. Hamasaki, N. Nakamura, A. Noda, and Y. Kodama, The Association of Radiation Exposure with Stable Chromosome Aberrations in Atomic Bomb Survivors Based on DS02R1 Dosimetry and FISH Methods. Radiat Res, 2023. 199(2): p. 170-181.
Tatsukawa, Y., K.A. Cordova, M. Yamada, W. Ohishi, M. Imaizumi, A. Hida, R. Sposto, R. Sakata, S. Fujiwara, S. Nakanishi, and M. Yoneda, Incidence of diabetes in the atomic bomb survivors: 1969-2015. J Clin Endocrinol Metab, 2022. 107(5): p. e2148-55.
Sposto, R., T.H.M. Keegan, C. Vigen, M.L. Kwan, L. Bernstein, E.M. John, I. Cheng, J. Yang, J. Koo, A.W. Kurian, B.J. Caan, Y.N. Lu, K.R. Monroe, S. Shariff-Marco, S.L. Gomez, and A.H. Wu. The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality. Cancer Epidemiology Biomarkers & Prevention. 2016; 25(7): 1064-1072.
Sposto, R. and P.S. Gaynon. An adjustment for patient heterogeneity in the design of two-stage phase II trials. Statistics in Medicine. 2009; 28(20): 2566 – 2579.
Sposto, R., W.B. London, and T.A. Alonzo. Criteria for optimizing prognostic risk groups in pediatric cancer: analysis of data from the Children’s Oncology Group. Journal of Clinical Oncology. 2007; 25(15): 2070-77.
Sposto, R. Cure model analysis in cancer: An application to data from the Children’s Cancer Group. Statistics in Medicine. 2002; 21: 293-312.
Sposto, R. and D.O. Stram. A strategic view of randomized trial design in low-incidence paediatric cancer. Statistics in Medicine. 1999; 18(10): 1183-97.
Sposto, R., D.L. Preston, Y. Shimizu, and K. Mabuchi. The effect of diagnostic misclassification on non-cancer and cancer mortality dose response in A-bomb survivors. Biometrics. 1992; 48(2): 605-17.
Sposto, R., D.O. Stram, and A.A. Awa. An estimate of the magnitude of random errors in the DS86 dosimetry from data on chromosome aberrations and severe epilation. Radiation Research. 1991; 128(2): 157-69.