Tomonori Hayashi

Affiliation

Department of Molecular Biosciences (Concurrently assigned to the Biosample Research Center)
E-mail: tomo@rerf.or.jp

About

Dr. Tomonori Hayashi has been studying the immunology of A-bomb survivors in the Immunology Laboratory of the Department of Radiobiology (now the Department of Molecular Biosciences) at RERF since 1990. He was a research fellow at Michigan State University (MSU), USA, from 1993 to 1995, where he studied cell-cell communication and mechanisms of human breast cancer development. He returned to Japan in 1995 and has been studying the effects of radiation exposure on the immune system of atomic bomb survivors and the genetic background of the relationship between radiation exposure and the development of radiation-related cancer and non-cancer diseases. His current interests include clarifying the effects of radiation exposure on immunological aging and whether differences in the genetic backgrounds of A-bomb survivors influenced the development of radiation-related diseases by comprehensive genome studies.

Education

1989
Doctor of Philosophy, Pharmaceutical Science, Graduate School of Pharmaceutical Science, Hiroshima University School of Medicine, Japan.
1982
Master of Science, Pharmaceutical Science, Nagasaki University Graduate School of Pharmaceutical Science, Japan.
1980
Bachelor of Arts, Pharmaceutical Science, Faculty of Pharmaceutical Science, Nagasaki University, Japan.

Experience

Radiation Effects Research Foundation
  • 2010-

    Senior Scientist, and Assistant Department Chief, Department of Molecular Biosciences

  • 2005-2018

    Senior Scientist, and Chief of Immunology Laboratory, Department of Molecular Biosciences

  • 2003-2005

    Senior Scientist, Immunology Laboratory, Department of Radiobiology/Molecular Epidemiology

  • 1995-2003

    Research Scientist, Immunology Laboratory, Department of Radiobiology/Molecular Epidemiology

  • 1990-1993

    Research Scientist, Immunology Laboratory, Department of Radiobiology
Michigan State University, Lansing, Michigan, USA
  • 1993-1995

    Research Scientist, Department of Pediatrics and Human Development

Hiroshima University School of Medicine
  • 1985-1989

    Research Scientist, Department of Analytical Chemistry

Wakunaga Pharmaceutical Co., Ltd
  • 1982-1990

    Research Scientist, Institute of Biotechnology Research Laboratories

Selected publications

Hayashi T, Furukawa K, Morishita Y, Hayashi I, Kato N, Yoshida K, Kusunoki Y, Kyoizumi S, Ohishi W. Intracellular reactive oxygen species level in blood cells of atomic bomb survivors is increased due to aging and radiation exposure. Free Radical Biol Med. 2021; 171:126-34. doi:10.1016/j.freeradbiomed.2021.05.017.
Hayashi T, Lynch HE, Geyer S, YoshidaK, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski GD, Nakachi K. Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort. Vaccine. 2018; 36(45):6650-6659. doi: 10.1016/j.vaccine.2018.09.054.
Hayashi T, Lynch HE, Geyer SM, French B, Yoshida K, Furudoi K, Sasaki K, Morishita Y, Nagamura H, Maki M, Hu Y, Hayashi I, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Shterev I, Nikolich-Zugich J, Murasko D, Sempowski GD, Nakachi K. Influenza Vaccine Response among Hiroshima Atomic-bomb Survivors. Hiroshima Igaku [J Hiroshima Med Assoc]. 2018; 71(4):278-82.
Lustig A, Shterev I, Geyer S, Shi A, Hu Y, Morishita Y, Nagamura H, Sasaki K, Maki M, Hayashi I, Furukawa K, Yoshida K, Kajimura J, Kyoizumi S, Kusunoki Y, Ohishi W, Nakachi K, Weng NP, Hayashi T. Long term effects of radiation exposure on telomere lengths of leukocytes and its associated biomarkers among atomic-bomb survivors. Oncotarget. 2016; 7(26):38988-98. doi: 10.18632/oncotarget.8801.
Hayashi T, Hu Y, Yoshida K, Ohishi W, Hida A, Hayashi I, Kyoizumi S, Kusunoki Y, Nakachi K. Radiation-associated breast cancer risk and ATM genotypes among atomic-bomb survivors. Hiroshima Medical Journal. 2016; 69(4):277-80.
Hu Y, Yoshida K, Cologne JB, Maki M, Morishita Y, Sasaki K, Hayashi I, Ohishi W, Hida A, Kyoizumi S, Kusunoki Y, Tokunaga K, Nakachi K, Hayashi T. CD14 and IL18 gene polymorphisms associated with colorectal cancer subsite risks among atomic bomb survivors. Hum Genome Var. 2015; 2:15035. doi: 10.1038/hgv.2015.35.
Hayashi T, Ito R, Cologne J, Maki M, Morishita Y, Nagamura H, Sasaki K, Hayashi I, Imai K, Yoshida K, Kajimura J, Kyoizumi S, Kusunoki Y, Ohishi W, Fujiwara S, Akahoshi M, Nakachi K. Effects of IL-10 haplotype and atomic-bomb radiation exposure on gastric cancer risk. Radiat Res. 2013; 180(1):60-9. doi: 10.1667/RR3183.1.
Hayashi T, Morishita Y, Khattree R, Misumi M, Sasaki K, Hayashi I, Yoshida K, Kajimura J, Kyoizumi S, Imai K, Kusunoki Y, Nakachi K. Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects. FASEB J. 2012; 26:4765-73.
Hayashi T, Imai K, Morishita Y, Hayashi I, Kusunoki Y, Nakachi K. Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral-blood lymphocytes and cancer immunosurveillance. Cancer Res. 2006; 66: 563-70.
Hayashi T., Morishita, Y., Kubo, Y., Kusunoki, Y., Hayashi, I., Kasagi, F., Hakoda, M., Kyoizumi, S., Nakachi, K. Long-term effects of radiation dose on inflammatory markers in atomic bomb survivors. Am J Med. 2005; 118: 83-6.

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